Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | KDM6B | O15054 | 1/20 | 0.46 |
| ▸ | KDM5C | P41229 | 1/20 | 0.46 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.46 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.46 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.46 |
| ▸ | KDM5A | P29375 | 1/20 | 0.46 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19629777 | 0.87 | CA1 (0.51) | KDM4EALOX15L3MBTL1KDM6BKDM5C | |
| SCHEMBL19615942 | 0.87 | CA1 (0.51) | KDM4EALOX15L3MBTL1KDM6BKDM5C | |
| SCHEMBL19631865 | 0.86 | KDM4E (0.55) | KDM4EALOX15L3MBTL1KDM6BKDM5C | |
| SCHEMBL19615810 | 0.86 | KDM4E (0.55) | KDM4EALOX15L3MBTL1KDM6BKDM5C | |
| SCHEMBL19615988 | 0.83 | KDM4E (0.50) | KDM4EALOX15L3MBTL1KDM6BKDM5C | |
| SCHEMBL19615658 | 0.83 | KDM5B (0.56) | KDM4EKDM6BKDM5CKDM4CKDM2A | |
| SCHEMBL29278627 | 0.79 | KDM4E (0.55) | KDM4EALOX15L3MBTL1KDM6BKDM5C | |
| SCHEMBL20963391 | 0.79 | KDM4E (0.55) | KDM4EALOX15L3MBTL1KDM6BKDM5C | |
| SCHEMBL30745058 | 0.79 | KDM4E (0.55) | KDM4EALOX15L3MBTL1KDM6BKDM5C | |
| SCHEMBL19632252 | 0.79 | NPC1 (0.52) | KDM4EALOX15L3MBTL1KDM6BKDM5C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017198785-A1 | OXIME DERIVATIVES USEFUL AS INHIBITORS OF HISTONE DEMETHYLASE KDM4C | IEO - ISTITUTO EUROPEO DI ONCOLOGIA S.R.L. (IT) | 2017-11-23 | — | — | WO | claimed |
| WO-2017198785-A1 | OXIME DERIVATIVES USEFUL AS INHIBITORS OF HISTONE DEMETHYLASE KDM4C | IEO - ISTITUTO EUROPEO DI ONCOLOGIA S.R.L. (IT) | 2017-11-23 | — | — | WO | disclosed |
| WO-2017198785-A1 | OXIME DERIVATIVES USEFUL AS INHIBITORS OF HISTONE DEMETHYLASE KDM4C | IEO - ISTITUTO EUROPEO DI ONCOLOGIA S.R.L. (IT) | 2017-11-23 | — | — | WO | disclosed |