Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 19/20 | 0.60 |
| ▸ | NEK4 | P51957 | 2/20 | 0.60 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.60 |
| ▸ | CAMK2B | Q13554 | 2/20 | 0.60 |
| ▸ | CAMK2G | Q13555 | 2/20 | 0.60 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.60 |
| ▸ | HIPK2 | Q9H2X6 | 2/20 | 0.60 |
| ▸ | MAP3K20 | Q9NYL2 | 2/20 | 0.60 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.60 |
| ▸ | EEF2K | O00418 | 1/20 | 0.60 |
| ▸ | MARK3 | P27448 | 1/20 | 0.60 |
| ▸ | AXL | P30530 | 1/20 | 0.60 |
| ▸ | BCL6 | P41182 | 1/20 | 0.60 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.60 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.60 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.60 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.60 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.45 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19635254 | 0.92 | MCL1 (0.70) | MCL1NEK4PRKCDCAMK2BCAMK2G | |
| SCHEMBL19615840 | 0.90 | MCL1 (0.60) | MCL1NEK4PRKCDCAMK2BCAMK2G | |
| SCHEMBL19635928 | 0.90 | MCL1 (0.60) | MCL1NEK4PRKCDCAMK2BCAMK2G | |
| SCHEMBL19618996 | 0.89 | MCL1 (0.60) | MCL1NEK4PRKCDCAMK2BCAMK2G | |
| SCHEMBL19635007 | 0.88 | MCL1 (0.57) | MCL1NEK4PRKCDCAMK2BCAMK2G | |
| SCHEMBL19635495 | 0.88 | MCL1 (0.58) | MCL1NEK4PRKCDCAMK2BCAMK2G | |
| SCHEMBL19615296 | 0.87 | MCL1 (0.62) | MCL1NEK4PRKCDCAMK2BCAMK2G | |
| SCHEMBL29602090 | 0.87 | MCL1 (0.62) | MCL1NEK4PRKCDCAMK2BCAMK2G | |
| SCHEMBL19615796 | 0.86 | MCL1 (0.60) | MCL1NEK4PRKCDCAMK2BCAMK2G | |
| SCHEMBL19634980 | 0.86 | MCL1 (0.59) | MCL1NEK4PRKCDCAMK2BCAMK2G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11492358-B1 | Macrocyclic indole derivatives | THE BROAD INSTITUTE, INC. (US) | 2022-11-08 | — | — | US | disclosed |
| EP-3458459-B1 | MACROCYCLIC INDOLE DERIVATIVES | BAYER AG (DE) | 2022-04-27 | — | — | EP | disclosed |
| EP-3458459-B1 | MACROCYCLIC INDOLE DERIVATIVES | BAYER AG (DE) | 2022-04-27 | — | — | EP | disclosed |
| CN-109715632-B | Macrocyclic indole derivatives | 拜尔公开股份有限公司 | 2021-10-26 | — | — | CN | disclosed |
| US-10981932-B2 | Macrocyclic indole derivatives | BAYER AKTIENGESELLSCHAFT (DE) | 2021-04-20 | — | — | US | disclosed |
| US-10981932-B2 | Macrocyclic indole derivatives | BAYER AKTIENGESELLSCHAFT (DE) | 2021-04-20 | — | — | US | disclosed |
| US-20200087322-A1 | MACROCYCLIC INDOLE DERIVATIVES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2020-03-19 | — | — | US | disclosed |
| EP-3458459-A1 | MACROCYCLIC INDOLE DERIVATIVES | Bayer Aktiengesellschaft (DE) | 2019-03-27 | — | — | EP | disclosed |
| WO-2017198341-A1 | MACROCYCLIC INDOLE DERIVATIVES | BAYER AKTIENGESELLSCHAFT (DE) | 2017-11-23 | — | — | WO | disclosed |
| WO-2017198341-A1 | MACROCYCLIC INDOLE DERIVATIVES | BAYER AKTIENGESELLSCHAFT (DE) | 2017-11-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11492358-B1 | Macrocyclic indole derivatives | CCND2, CCNT2, IDO1 | MCL1 54/4885NEK4 1431/4885PRKCD 1885/4885 |
| US-10981932-B2 | Macrocyclic indole derivatives | CCND2, IDO1, CCNT2 | MCL1 62/4885NEK4 1215/4885PRKCD 1277/4885 |
| US-20200087322-A1 | MACROCYCLIC INDOLE DERIVATIVES | CCND2, CCNA1, CCNT2 | MCL1 56/4885NEK4 1497/4885PRKCD 1854/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.