Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 20/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22440324 | 0.96 | KRAS (0.59) | KRAS | |
| SCHEMBL19616748 | 0.93 | KRAS (0.61) | KRAS | |
| SCHEMBL19617418 | 0.93 | KRAS (0.61) | KRAS | |
| SCHEMBL19616477 | 0.92 | KRAS (0.52) | KRAS | |
| SCHEMBL22440330 | 0.92 | KRAS (0.62) | KRAS | |
| SCHEMBL22440233 | 0.91 | KRAS (0.48) | KRAS | |
| SCHEMBL22440261 | 0.90 | KRAS (0.53) | KRAS | |
| SCHEMBL19616626 | 0.90 | KRAS (0.61) | KRAS | |
| SCHEMBL19616802 | 0.89 | KRAS (0.65) | KRAS | |
| SCHEMBL19617141 | 0.89 | KRAS (0.59) | KRAS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3710439-A1 | KRAS G12C INHIBITORS | Mirati Therapeutics, Inc. (US) | 2020-09-23 | — | — | EP | disclosed |
| EP-3458445-A1 | KRAS G12C INHIBITORS | Mirati Therapeutics, Inc. (US) | 2019-03-27 | — | — | EP | disclosed |
| WO-2017201161-A1 | KRAS G12C INHIBITORS | Mirati Therapeutics, Inc. (US) | 2017-11-23 | — | — | WO | disclosed |