SCHEMBL19617539

SCHEMBL19617539

O=S(=O)(Nc1nccs1)c1ccc(OC2C[C@@H]3CC[C@@H](C2)N3Cc2ccccc2)c(Cl)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SCN8A Q9UQD0 20/20 1.00
SCN1A P35498 15/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19613414 1.00 SCN8A (1.00) SCN8ASCN1A
SCHEMBL19617541 1.00 SCN8A (1.00) SCN8ASCN1A
SCHEMBL19613409 1.00 SCN8A (1.00) SCN8ASCN1A
SCHEMBL19613416 1.00 SCN8A (1.00) SCN8ASCN1A
SCHEMBL19613411 1.00 SCN8A (1.00) SCN8ASCN1A
SCHEMBL19613332 0.86 SCN8A (1.00) SCN8ASCN1A
SCHEMBL19612876 0.86 SCN8A (1.00) SCN8ASCN1A
SCHEMBL19617687 0.86 SCN8A (1.00) SCN8ASCN1A
SCHEMBL19617688 0.86 SCN8A (1.00) SCN8ASCN1A
SCHEMBL19613326 0.86 SCN8A (1.00) SCN8ASCN1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3458449-A1 BENZENESULFONAMIDE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS Xenon Pharmaceuticals Inc. (CA) 2019-03-27 EP disclosed
WO-2017201468-A1 BENZENESULFONAMIDE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS XENON PHARMACEUTICALS INC. (CA) 2017-11-23 WO disclosed