Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.41 |
| ▸ | GABRP | O00591 | 4/20 | 0.36 |
| ▸ | GABRD | O14764 | 4/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.36 |
| ▸ | GABRB1 | P18505 | 4/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 4/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 4/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 4/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 4/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.36 |
| ▸ | GABRA4 | P48169 | 4/20 | 0.36 |
| ▸ | GABRE | P78334 | 4/20 | 0.36 |
| ▸ | GABRA6 | Q16445 | 4/20 | 0.36 |
| ▸ | GABRG1 | Q8N1C3 | 4/20 | 0.36 |
| ▸ | GABRG3 | Q99928 | 4/20 | 0.36 |
| ▸ | GABRQ | Q9UN88 | 4/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.32 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Alanine SCHEMBL27304595 | 0.88 | SLC7A5 (0.48) | SLC7A5GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL5946162 | 0.87 | — | — | |
| SCHEMBL27813803 | 0.87 | DPP4 (0.38) | SLC7A5GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL341359 | 0.87 | — | — | |
| SCHEMBL27592362 | 0.83 | — | — | |
| SCHEMBL28009276 | 0.83 | — | — | |
| Hydrochloric Acid SCHEMBL11571407 | 0.83 | — | — | |
| Hydrogen Sulfide SCHEMBL28083364 | 0.83 | — | — | |
| Hydrochloric Acid SCHEMBL27519491 | 0.83 | — | — | |
| Ethylene SCHEMBL27627224 | 0.80 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017201278-A1 | THIOESTER PRODRUGS OF MACROCYCLES AS INHIBITORS OF HISTONE DEACETYLASES | ONKURE, INC. (US) | 2017-11-23 | — | — | WO | disclosed |