Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 4/20 | 0.53 |
| ▸ | MTOR | P42345 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 11/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 11/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 11/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 11/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 11/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 11/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 11/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 11/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 11/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 11/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 11/20 | 0.42 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL179448 | 0.90 | PIK3CA (0.56) | PIK3CAMTORKMT2AHDAC3HDAC4 | |
| SCHEMBL179420 | 0.90 | PIK3CA (0.56) | PIK3CAMTORKMT2AHDAC3HDAC4 | |
| SCHEMBL179421 | 0.90 | PIK3CA (0.56) | PIK3CAMTORKMT2AHDAC3HDAC4 | |
| SCHEMBL4572146 | 0.85 | PIK3CA (0.56) | PIK3CAMTORKMT2AHDAC3HDAC4 | |
| SCHEMBL239360 | 0.85 | PIK3CA (0.56) | PIK3CAMTORKMT2AHDAC3HDAC4 | |
| SCHEMBL244324 | 0.85 | PIK3CA (0.56) | PIK3CAMTORKMT2AHDAC3HDAC4 | |
| SCHEMBL5019512 | 0.85 | PIK3CA (0.71) | PIK3CAMTORKMT2AHDAC3HDAC4 | |
| SCHEMBL19261367 | 0.83 | PIK3CA (0.54) | PIK3CAMTORKMT2AHDAC3HDAC4 | |
| SCHEMBL9924586 | 0.82 | PIK3CA (0.58) | PIK3CAMTORKMT2AHDAC3HDAC4 | |
| SCHEMBL15679247 | 0.82 | PIK3CA (0.58) | PIK3CAMTORKMT2AHDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9822131-B2 | Certain chemical entities, compositions and methods | INTELLIKINE LLC (US) | 2017-11-21 | — | — | US | disclosed |