⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dimebutic Acid SCHEMBL47533 | 0.97 | — | — | |
| Dimebutic Acid SCHEMBL1055427 | 0.94 | — | — | |
| Dimebutic Acid SCHEMBL1961089 | 0.94 | — | — | |
| Dimebutic Acid SCHEMBL28444780 | 0.94 | — | — | |
| Dimebutic Acid SCHEMBL27976584 | 0.94 | — | — | |
| Dimebutic Acid SCHEMBL25275531 | 0.94 | — | — | |
| Dimebutic Acid SCHEMBL8383027 | 0.94 | — | — | |
| Dimebutic Acid SCHEMBL1176300 | 0.94 | — | — | |
| Dimebutic Acid SCHEMBL20139427 | 0.94 | — | — | |
| Dimebutic Acid SCHEMBL27959638 | 0.94 | TSHR (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9018176-B2 | Inducers of hematopoiesis and fetal globin production for treatment of cytopenias and hemoglobin disorders | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-04-28 | — | — | US | disclosed |
| WO-2015026939-A1 | CHEMICAL INDUCERS OF FETAL HEMOGLOBIN | PHOENICIA BIOSCIENCES, INC. (US) | 2015-02-26 | — | — | WO | disclosed |
| US-8618068-B2 | Methods and low dose regimens for treating red blood cell disorders | TRUSTEES OF BOSTON UNIVERSITY (US) | 2013-12-31 | — | — | US | disclosed |
| EP-2509418-A1 | METHODS AND LOW DOSE REGIMENS FOR TREATING RED BLOOD CELL DISORDERS | Hemaquest Pharmaceuticals, Inc. (US) | 2012-10-17 | — | — | EP | disclosed |
| WO-2011072086-A9 | METHODS AND LOW DOSE REGIMENS FOR TREATING RED BLOOD CELL DISORDERS | HEMAQUEST PHARMACEUTICALS, INC. (US) | 2012-09-27 | — | — | WO | disclosed |
| US-20110251149-A1 | METHODS AND LOW DOSE REGIMENS FOR TREATING RED BLOOD CELL DISORDERS | TRUSTEES OF BOSTON UNIVERSITY (US) | 2011-10-13 | — | — | US | disclosed |
| WO-2011072086-A1 | METHODS AND LOW DOSE REGIMENS FOR TREATING RED BLOOD CELL DISORDERS | HEMAQUEST PHARMACEUTICALS, INC. (US) | 2011-06-16 | — | — | WO | disclosed |