SCHEMBL19620374

SCHEMBL19620374

CCOc1ccc(Cc2cc(N)ccc2Cl)cc1

nearest known ligand 0.53

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
SLC5A2 P31639 15/20 0.53
TSHR P16473 1/20 0.53
TDP1 Q9NUW8 1/20 0.53
SLC5A1 P13866 9/20 0.52
SMN1; SMN2 Q16637 2/20 0.51
KDM4E B2RXH2 1/20 0.51
HPGD P15428 1/20 0.51
ADRA2A P08913 1/20 0.50
SLC5A11 Q8WWX8 1/20 0.50
DHFR P00374 1/20 0.50
LMNA P02545 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11313959 0.84 SLC5A2 (0.55) SLC5A2SLC5A1ADRA2ASLC5A11
SCHEMBL12110835 0.84 TDP1 (0.56) TSHRTDP1SMN1; SMN2KDM4EHPGD
SCHEMBL2707322 0.83 SLC5A2 (0.54) SLC5A2SLC5A1ADRA2ASLC5A11
SCHEMBL2871442 0.83 SLC5A2 (0.54) SLC5A2SLC5A1ADRA2ASLC5A11
SCHEMBL27969548 0.82 SLC5A2 (0.51) SLC5A2SLC5A1SMN1; SMN2HPGDADRA2A
SCHEMBL29455231 0.82 SLC5A2 (0.53) SLC5A2SLC5A1ADRA2ASLC5A11
SCHEMBL29386304 0.82 SLC5A2 (0.53) SLC5A2SLC5A1ADRA2ASLC5A11
SCHEMBL38150 0.82 SLC5A2 (0.53) SLC5A2SLC5A1ADRA2ASLC5A11
SCHEMBL14608649 0.82 SLC5A2 (0.53) SLC5A2SLC5A1ADRA2ASLC5A11
SCHEMBL1933786 0.82 SLC5A2 (0.53) SLC5A2SLC5A1ADRA2ASLC5A11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210323939-A1 NOVEL PROCESSES FOR PREPARATION OF DAPAGLIFLOZIN OR ITS SOLVATES OR CO-CRYSTALS THEREOF LAURUS LABS LIMITED (IN) 2021-10-21 US disclosed
WO-2018029611-A1 NOVEL PROCESSES FOR PREPARATION OF DAPAGLIFLOZIN OR ITS SOLVATES OR CO-CRYSTALS THEREOF LAURUS LABS LIMITED (IN) 2018-02-15 WO disclosed
EP-3246324-A2 PHENYL C-GLUCOSIDE DERIVATIVE CONTAINING DEOXYGLUCOSE STRUCTURE, PREPARATION METHOD AND USES THEREOF Tianjin Institute Of Pharmaceutical Research (CN) 2017-11-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210323939-A1 NOVEL PROCESSES FOR PREPARATION OF DAPAGLIFLOZIN OR ITS SOLVATES OR CO-CRYSTALS THEREOF SLC5A1, SLC5A2, DPP4 SLC5A2 2/4885TSHR 3697/4885TDP1 3205/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.