Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 8/20 | 0.56 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.32 |
| ▸ | PPARA | Q07869 | 3/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | NAMPT | P43490 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1962039 | 1.00 | GCK (0.56) | GCKGPR119KMT2ACCNE1CDK2 | |
| SCHEMBL1960158 | 0.90 | GCK (0.53) | GCKGPR119KMT2ACCNE1CDK2 | |
| SCHEMBL1960157 | 0.90 | GCK (0.53) | GCKGPR119KMT2ACCNE1CDK2 | |
| SCHEMBL1961702 | 0.87 | GCK (0.59) | GCKGPR119KMT2ACYP2C9NAMPT | |
| SCHEMBL1961701 | 0.87 | GCK (0.59) | GCKGPR119KMT2ACYP2C9NAMPT | |
| SCHEMBL1962902 | 0.86 | GCK (0.58) | GCKKMT2A | |
| SCHEMBL1962903 | 0.86 | GCK (0.58) | GCKKMT2A | |
| SCHEMBL1960935 | 0.84 | GCK (0.55) | GCKKMT2A | |
| SCHEMBL1959072 | 0.84 | GCK (0.55) | GCK | |
| SCHEMBL1960933 | 0.84 | GCK (0.55) | GCKKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8222416-B2 | Azaindole glucokinase activators | HOFFMANN-LA ROCHE INC. (US) | 2012-07-17 | — | — | US | disclosed |
| US-20110144105-A1 | AZAINDOLE GLUCOKINASE ACTIVATORS | BERTHEL STEVEN JOSEPH | 2011-06-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110144105-A1 | AZAINDOLE GLUCOKINASE ACTIVATORS | GCK, GCKR, GALK1 | GCK 1/4885GPR119 6/4885KMT2A 1524/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.