SCHEMBL19620528

SCHEMBL19620528

NC1=C(OSCc2ccccc2)C(=O)C(c2ccccc2Cl)O1

nearest known ligand 0.36

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
DPP4 P27487 2/20 0.36
CYP1A2 P05177 1/20 0.34
CYP3A4 P08684 1/20 0.34
CYP2C19 P33261 1/20 0.34
KDM4E B2RXH2 1/20 0.33
POLB P06746 1/20 0.33
MAPT P10636 1/20 0.33
ADK P55263 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
PYGL P06737 1/20 0.31
PYGM P11217 1/20 0.31
TSHR P16473 1/20 0.31
HTR2A P28223 1/20 0.31
HTR2C P28335 1/20 0.31
HTR2B P41595 1/20 0.31
F2 P00734 1/20 0.30
F10 P00742 1/20 0.30
PRSS1 P07477 1/20 0.30
SLC6A3 Q01959 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19620512 0.92 HTR2A (0.33) DPP4CYP1A2CYP3A4CYP2C19KDM4E
SCHEMBL19620537 0.90 CYP1A2 (0.32) CYP1A2CYP3A4CYP2C19KDM4EPOLB
SCHEMBL19620486 0.89 HTT (0.39) DPP4CYP1A2CYP3A4CYP2C19KDM4E
SCHEMBL19620669 0.89 CYP1A2 (0.34) DPP4CYP1A2CYP3A4CYP2C19KDM4E
SCHEMBL19620663 0.87 CYP3A4 (0.33) CYP1A2CYP3A4CYP2C19MAPT
SCHEMBL19620515 0.87 CYP1A2 (0.33) DPP4CYP1A2CYP3A4CYP2C19ADK
SCHEMBL19620578 0.87 HTR2A (0.34) DPP4CYP1A2CYP3A4CYP2C19ADK
SCHEMBL19620649 0.87 HTT (0.34) CYP1A2CYP3A4CYP2C19KDM4EMAPT
SCHEMBL19620625 0.85 CYP1A2 (0.34) CYP1A2CYP3A4CYP2C19KDM4EPOLB
SCHEMBL19620571 0.83 HTR2C (0.35) CYP1A2CYP3A4CYP2C19KDM4EPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3345596-B1 INHIBITORS OF BETA-HYDROLASE FOR TREATMENT OF CANCER RHODE ISLAND HOSPITAL (US) 2021-01-20 EP disclosed
EP-3345596-A2 INHIBITORS OF BETA-HYDROLASE FOR TREATMENT OF CANCER RHODE ISLAND HOSPITAL (US) 2018-07-11 EP disclosed
EP-2897607-B1 INHIBITORS OF BETA-HYDROLASE FOR TREATMENT OF CANCER RHODE ISLAND HOSPITAL (US) 2017-11-22 EP disclosed