Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 18/20 | 0.70 |
| ▸ | EZH1 | Q92800 | 4/20 | 0.64 |
| ▸ | EED | O75530 | 6/20 | 0.56 |
| ▸ | SUZ12 | Q15022 | 6/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | RBBP4 | Q09028 | 2/20 | 0.50 |
| ▸ | AEBP2 | Q6ZN18 | 2/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2592723 | 0.94 | EZH2 (0.61) | EZH2EZH1EEDSUZ12HDAC1 | |
| SCHEMBL19620940 | 0.89 | EZH2 (0.66) | EZH2EZH1EEDSUZ12HDAC1 | |
| SCHEMBL12180083 | 0.86 | EZH2 (0.85) | EZH2EZH1EEDSUZ12HDAC1 | |
| SCHEMBL19620804 | 0.85 | EZH2 (0.72) | EZH2EZH1EEDSUZ12RBBP4 | |
| SCHEMBL19620903 | 0.84 | EZH2 (0.69) | EZH2EZH1EEDSUZ12HDAC1 | |
| SCHEMBL14717385 | 0.84 | EZH2 (0.71) | EZH2EZH1EEDSUZ12RBBP4 | |
| SCHEMBL2594806 | 0.84 | EZH2 (0.75) | EZH2EZH1EEDSUZ12HDAC1 | |
| SCHEMBL19620967 | 0.83 | EZH2 (0.67) | EZH2EZH1EEDSUZ12HDAC1 | |
| SCHEMBL2594531 | 0.83 | EZH2 (0.58) | EZH2EZH1 | |
| SCHEMBL12180194 | 0.82 | EZH2 (0.65) | EZH2EZH1EEDSUZ12HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3246027-A1 | INDOLE DERIVATIVES FOR THE TREATMENT OF CANCER | GlaxoSmithKline LLC (US) | 2017-11-22 | — | — | EP | disclosed |