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SCHEMBL19620792

SCHEMBL19620792

CSc1cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c2c(C)cn(C(C)C)c2c1

nearest known ligand 0.63

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ EZH2 Q15910 18/20 0.63
▸ EZH1 Q92800 3/20 0.59
▸ EED O75530 3/20 0.51
▸ SUZ12 Q15022 3/20 0.51
▸ BRD4 O60885 1/20 0.47
▸ RBBP4 Q09028 2/20 0.47
▸ RBBP7 Q16576 1/20 0.47
▸ HDAC1 Q13547 1/20 0.47
▸ AEBP2 Q6ZN18 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12180137 0.88 EZH2 (0.65) EZH2EZH1EEDSUZ12BRD4
SCHEMBL30620946 0.87 EZH2 (0.64) EZH2EZH1EEDSUZ12RBBP4
SCHEMBL12180391 0.87 EZH2 (0.64) EZH2EZH1EEDSUZ12BRD4
SCHEMBL2587499 0.87 EZH2 (0.64) EZH2EZH1EEDSUZ12BRD4
SCHEMBL17584932 0.87 EZH2 (0.64) EZH2EZH1EEDSUZ12BRD4
SCHEMBL2592559 0.87 EZH2 (0.64) EZH2EZH1EEDSUZ12RBBP4
SCHEMBL17970545 0.87 EZH2 (0.56) EZH2EZH1EEDSUZ12BRD4
SCHEMBL12180202 0.86 EZH2 (0.56) EZH2EZH1EEDSUZ12BRD4
SCHEMBL12180107 0.86 EZH2 (0.62) EZH2EZH1EEDSUZ12BRD4
SCHEMBL12180429 0.86 EZH2 (0.62) EZH2EZH1EEDSUZ12RBBP4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3246027-A1 INDOLE DERIVATIVES FOR THE TREATMENT OF CANCER GlaxoSmithKline LLC (US) 2017-11-22 — — EP disclosed