Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 19/20 | 0.42 |
| ▸ | EZH1 | Q92800 | 3/20 | 0.40 |
| ▸ | EED | O75530 | 3/20 | 0.38 |
| ▸ | SUZ12 | Q15022 | 3/20 | 0.38 |
| ▸ | RBBP4 | Q09028 | 2/20 | 0.38 |
| ▸ | AEBP2 | Q6ZN18 | 2/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.35 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14717635 | 0.85 | EZH2 (0.57) | EZH2EZH1EEDSUZ12RBBP4 | |
| SCHEMBL19620822 | 0.79 | EZH2 (0.66) | EZH2EZH1EEDSUZ12RBBP4 | |
| SCHEMBL18864309 | 0.76 | EZH2 (0.47) | EZH2EZH1EEDSUZ12RBBP4 | |
| SCHEMBL14717877 | 0.76 | EZH2 (0.64) | EZH2EZH1EEDSUZ12RBBP4 | |
| SCHEMBL18864307 | 0.75 | EZH2 (0.46) | EZH2EZH1EEDSUZ12RBBP4 | |
| SCHEMBL18864353 | 0.74 | EZH2 (0.51) | EZH2EZH1EEDSUZ12RBBP4 | |
| SCHEMBL14717539 | 0.73 | EZH2 (0.65) | EZH2EZH1EEDSUZ12RBBP4 | |
| SCHEMBL19620906 | 0.73 | EZH2 (0.52) | EZH2EZH1EEDSUZ12RBBP4 | |
| SCHEMBL19621002 | 0.73 | EZH2 (0.46) | EZH2EZH1EEDSUZ12RBBP4 | |
| SCHEMBL2595218 | 0.72 | EZH2 (0.61) | EZH2EZH1EEDSUZ12RBBP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3246027-A1 | INDOLE DERIVATIVES FOR THE TREATMENT OF CANCER | GlaxoSmithKline LLC (US) | 2017-11-22 | — | — | EP | disclosed |