Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 17/20 | 0.44 |
| ▸ | EZH1 | Q92800 | 3/20 | 0.44 |
| ▸ | EED | O75530 | 2/20 | 0.38 |
| ▸ | SUZ12 | Q15022 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.35 |
| ▸ | RBBP7 | Q16576 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | TTK | P33981 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12180121 | 0.85 | EZH2 (0.61) | EZH2EZH1EEDSUZ12HDAC1 | |
| SCHEMBL18864307 | 0.83 | EZH2 (0.46) | EZH2EZH1EEDSUZ12HDAC1 | |
| SCHEMBL18864309 | 0.81 | EZH2 (0.47) | EZH2EZH1EEDSUZ12HDAC1 | |
| SCHEMBL18863721 | 0.80 | EZH2 (0.49) | EZH2EZH1EEDSUZ12HDAC1 | |
| SCHEMBL18864353 | 0.79 | EZH2 (0.51) | EZH2EZH1EEDSUZ12HDAC1 | |
| SCHEMBL19621002 | 0.78 | EZH2 (0.46) | EZH2EZH1EEDSUZ12BRD4 | |
| SCHEMBL12180414 | 0.77 | EZH2 (0.60) | EZH2EZH1EEDSUZ12HDAC1 | |
| SCHEMBL19890902 | 0.76 | EZH2 (0.75) | EZH2EZH1EEDSUZ12HDAC1 | |
| SCHEMBL12180268 | 0.76 | EZH2 (0.64) | EZH2EZH1EEDSUZ12HDAC1 | |
| SCHEMBL12180412 | 0.74 | EZH2 (0.62) | EZH2EZH1EEDSUZ12HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3246027-A1 | INDOLE DERIVATIVES FOR THE TREATMENT OF CANCER | GlaxoSmithKline LLC (US) | 2017-11-22 | — | — | EP | disclosed |