Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 19/20 | 0.64 |
| ▸ | EZH1 | Q92800 | 4/20 | 0.64 |
| ▸ | EED | O75530 | 8/20 | 0.62 |
| ▸ | SUZ12 | Q15022 | 8/20 | 0.62 |
| ▸ | RBBP4 | Q09028 | 4/20 | 0.62 |
| ▸ | AEBP2 | Q6ZN18 | 4/20 | 0.62 |
| ▸ | RBBP7 | Q16576 | 2/20 | 0.62 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.58 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19570148 | 0.93 | EZH2 (0.70) | EZH2EZH1EEDSUZ12RBBP4 | |
| SCHEMBL19620827 | 0.85 | EZH2 (0.66) | EZH2EZH1EEDSUZ12RBBP4 | |
| SCHEMBL19620961 | 0.85 | EZH2 (0.66) | EZH2EZH1EEDSUZ12RBBP4 | |
| SCHEMBL2592674 | 0.84 | EZH2 (0.89) | EZH2EZH1EEDSUZ12RBBP4 | |
| SCHEMBL16115389 | 0.83 | EZH1 (0.72) | EZH2EZH1EEDSUZ12RBBP4 | |
| SCHEMBL16115016 | 0.83 | EZH2 (0.71) | EZH2EZH1EEDSUZ12RBBP4 | |
| SCHEMBL9286010 | 0.81 | EZH2 (0.69) | EZH2EZH1EEDSUZ12RBBP4 | |
| SCHEMBL19621001 | 0.80 | EZH2 (0.63) | EZH2EZH1EEDSUZ12RBBP4 | |
| SCHEMBL16680601 | 0.79 | EZH2 (0.72) | EZH2EZH1EEDSUZ12RBBP4 | |
| SCHEMBL2590359 | 0.79 | EZH2 (0.78) | EZH2EZH1EEDSUZ12RBBP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3246027-A1 | INDOLE DERIVATIVES FOR THE TREATMENT OF CANCER | GlaxoSmithKline LLC (US) | 2017-11-22 | — | — | EP | disclosed |