Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 20/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | EED | O75530 | 9/20 | 0.39 |
| ▸ | SUZ12 | Q15022 | 9/20 | 0.39 |
| ▸ | RBBP4 | Q09028 | 4/20 | 0.39 |
| ▸ | AEBP2 | Q6ZN18 | 3/20 | 0.39 |
| ▸ | EZH1 | Q92800 | 1/20 | 0.38 |
| ▸ | RBBP7 | Q16576 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2594899 | 0.90 | EZH2 (0.52) | EZH2BRD4EEDSUZ12RBBP4 | |
| SCHEMBL12180078 | 0.87 | EZH2 (0.57) | EZH2BRD4EEDSUZ12RBBP4 | |
| SCHEMBL2595647 | 0.79 | EZH2 (0.55) | EZH2BRD4EEDSUZ12RBBP4 | |
| SCHEMBL17584935 | 0.78 | EZH2 (0.57) | EZH2BRD4EEDSUZ12RBBP4 | |
| SCHEMBL2586392 | 0.76 | EZH2 (0.58) | EZH2EEDSUZ12RBBP4AEBP2 | |
| SCHEMBL12180390 | 0.76 | EZH2 (0.54) | EZH2BRD4EEDSUZ12RBBP4 | |
| SCHEMBL19620847 | 0.75 | EZH2 (0.61) | EZH2BRD4EEDSUZ12RBBP4 | |
| SCHEMBL12180403 | 0.74 | EZH2 (0.62) | EZH2BRD4EEDSUZ12RBBP4 | |
| SCHEMBL2592178 | 0.73 | EZH2 (0.61) | EZH2BRD4EEDSUZ12RBBP4 | |
| SCHEMBL12180273 | 0.73 | EZH2 (0.59) | EZH2BRD4EEDSUZ12RBBP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3246027-A1 | INDOLE DERIVATIVES FOR THE TREATMENT OF CANCER | GlaxoSmithKline LLC (US) | 2017-11-22 | — | — | EP | disclosed |