Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 20/20 | 0.58 |
| ▸ | PIK3R1 | P27986 | 7/20 | 0.58 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2378462 | 0.94 | PIK3CA (0.60) | PIK3CAPIK3R1PIK3CB | |
| SCHEMBL2377364 | 0.90 | PIK3CA (0.63) | PIK3CAPIK3R1PIK3CB | |
| SCHEMBL2376634 | 0.88 | PIK3CA (0.73) | PIK3CAPIK3R1PIK3CB | |
| SCHEMBL19623432 | 0.82 | PIK3CA (0.43) | PIK3CAPIK3R1 | |
| SCHEMBL19623538 | 0.82 | PIK3CA (0.59) | PIK3CAPIK3R1PIK3CB | |
| SCHEMBL2377737 | 0.82 | PIK3CA (0.64) | PIK3CAPIK3R1 | |
| Trifluoroacetic Acid SCHEMBL2376019 | 0.82 | PIK3CA (0.57) | PIK3CAPIK3R1 | |
| SCHEMBL12246791 | 0.81 | PIK3CA (0.61) | PIK3CAPIK3R1 | |
| SCHEMBL2377699 | 0.81 | PIK3CA (0.61) | PIK3CAPIK3R1PIK3CB | |
| SCHEMBL2377307 | 0.81 | PIK3CA (0.57) | PIK3CAPIK3R1PIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2050749-B1 | PYRIMIDINE DERIVATIVE AS PI3K INHIBITOR AND USE THEREOF | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2017-11-22 | — | — | EP | disclosed |