Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 20/20 | 0.73 |
| ▸ | PIK3R1 | P27986 | 7/20 | 0.61 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.55 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.55 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.55 |
| ▸ | MTOR | P42345 | 1/20 | 0.55 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19623721 | 0.89 | PIK3CA (0.69) | PIK3CAPIK3R1PIK3CDPIK3C2BPIK3CB | |
| SCHEMBL19623488 | 0.88 | PIK3CA (0.60) | PIK3CAPIK3R1PIK3CDPIK3C2BPIK3CB | |
| SCHEMBL19623445 | 0.87 | PIK3CA (0.76) | PIK3CAPIK3R1PIK3CDPIK3C2BPIK3CB | |
| SCHEMBL2376062 | 0.85 | PIK3CA (1.00) | PIK3CAPIK3R1PIK3CDPIK3C2BPIK3CB | |
| SCHEMBL19623747 | 0.84 | PIK3CA (0.84) | PIK3CAPIK3R1PIK3CDPIK3C2BPIK3CB | |
| SCHEMBL2377882 | 0.84 | PIK3CA (0.73) | PIK3CAPIK3R1PIK3CDPIK3C2BPIK3CB | |
| SCHEMBL2377215 | 0.82 | PIK3CA (1.00) | PIK3CAPIK3R1PIK3CDPIK3C2BPIK3CB | |
| SCHEMBL2377052 | 0.82 | PIK3CA (0.71) | PIK3CAPIK3R1PIK3CDPIK3C2BPIK3CB | |
| SCHEMBL19623484 | 0.82 | PIK3CA (0.60) | PIK3CAPIK3R1PIK3CDPIK3C2BPIK3CB | |
| SCHEMBL19623448 | 0.82 | PIK3CA (0.80) | PIK3CAPIK3R1PIK3CDPIK3C2BPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2050749-B1 | PYRIMIDINE DERIVATIVE AS PI3K INHIBITOR AND USE THEREOF | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2017-11-22 | — | — | EP | disclosed |