Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 20/20 | 0.51 |
| ▸ | PIK3R1 | P27986 | 5/20 | 0.49 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | AKT1 | P31749 | 1/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2376517 | 0.89 | PIK3CA (0.66) | PIK3CAPIK3R1 | |
| SCHEMBL25269771 | 0.86 | PIK3CA (0.58) | PIK3CAPIK3R1PIK3CDCYP3A4AKT1 | |
| SCHEMBL2378238 | 0.81 | PIK3CA (0.58) | PIK3CAPIK3R1AKT1 | |
| SCHEMBL2376510 | 0.80 | PIK3CA (0.64) | PIK3CAPIK3R1 | |
| SCHEMBL19623564 | 0.80 | PIK3CA (0.47) | PIK3CAPIK3R1 | |
| SCHEMBL19623541 | 0.78 | PIK3CA (0.55) | PIK3CAPIK3R1PIK3CBPIK3CG | |
| SCHEMBL2376771 | 0.77 | PIK3CA (0.60) | PIK3CAPIK3R1 | |
| SCHEMBL2376941 | 0.77 | PIK3CA (0.64) | PIK3CAPIK3R1 | |
| SCHEMBL3224544 | 0.76 | PIK3CA (0.71) | PIK3CAPIK3R1 | |
| SCHEMBL12246793 | 0.75 | PIK3CA (0.62) | PIK3CAPIK3R1PIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2050749-B1 | PYRIMIDINE DERIVATIVE AS PI3K INHIBITOR AND USE THEREOF | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2017-11-22 | — | — | EP | disclosed |