Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 19/20 | 0.73 |
| ▸ | PIK3R1 | P27986 | 9/20 | 0.48 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.45 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2376988 | 0.91 | PIK3CA (0.89) | PIK3CAPIK3R1PIK3CBPIK3CD | |
| SCHEMBL19623566 | 0.86 | PIK3CA (0.67) | PIK3CAPIK3R1PIK3CB | |
| SCHEMBL2379005 | 0.85 | PIK3CA (1.00) | PIK3CAPIK3R1 | |
| SCHEMBL2376782 | 0.83 | PIK3CA (0.89) | PIK3CAPIK3R1PIK3CBPIK3CD | |
| SCHEMBL2378115 | 0.81 | PIK3CA (0.85) | PIK3CAPIK3R1PIK3CB | |
| SCHEMBL2378950 | 0.80 | PIK3CA (0.90) | PIK3CAPIK3R1 | |
| SCHEMBL2376885 | 0.79 | PIK3CA (0.85) | PIK3CAPIK3R1PIK3CBPIK3CD | |
| SCHEMBL2378047 | 0.79 | PIK3CA (0.85) | PIK3CAPIK3R1PIK3CB | |
| SCHEMBL2378373 | 0.79 | PIK3CA (0.81) | PIK3CAPIK3R1PIK3CBPIK3CD | |
| SCHEMBL2379108 | 0.79 | PIK3CA (0.84) | PIK3CAPIK3R1PIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2050749-B1 | PYRIMIDINE DERIVATIVE AS PI3K INHIBITOR AND USE THEREOF | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2017-11-22 | — | — | EP | disclosed |