Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESRRG | P62508 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | F13A1 | P00488 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.35 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 2/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.34 |
| ▸ | TACR2 | P21452 | 2/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | SHBG | P04278 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.34 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19624118 | 0.80 | ESR1 (0.39) | KDM4EESR1ADRA2AADORA3TACR2 | |
| SCHEMBL19624135 | 0.78 | ESR1 (0.35) | KDM4EESR1ADRA2AADORA3TACR2 | |
| SCHEMBL19624233 | 0.77 | ESR1 (0.33) | KDM4EESR1ADRA2AADORA3TACR2 | |
| SCHEMBL19624315 | 0.77 | ESR1 (0.33) | KDM4ESIGMAR1ESR1ADRA2AADORA3 | |
| SCHEMBL19624363 | 0.75 | PTPN2 (0.32) | KDM4ESIGMAR1ESR1ADRA2AADORA3 | |
| SCHEMBL19624376 | 0.75 | ESR1 (0.32) | KDM4ESIGMAR1ESR1ADRA2AADORA3 | |
| SCHEMBL19624146 | 0.75 | KDM4E (0.31) | KDM4EF13A1SIGMAR1TMEM97ESR1 | |
| SCHEMBL19624340 | 0.74 | — | — | |
| SCHEMBL19624326 | 0.72 | ESR1 (0.33) | ESRRGKDM4EESR1ADRA2AADORA3 | |
| SCHEMBL19624245 | 0.70 | ESR1 (0.32) | KDM4EESR1ADRA2AADORA3TACR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3246330-A1 | IMIDAZOLES AS HISTONE DEMETHYLASE INHIBITORS | Istituto Europeo di Oncologia S.r.l. (IT) | 2017-11-22 | — | — | EP | disclosed |