Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 3/20 | 0.40 |
| ▸ | BTK | Q06187 | 9/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 3/20 | 0.39 |
| ▸ | LCK | P06239 | 3/20 | 0.39 |
| ▸ | ITK | Q08881 | 3/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | CKS1B | P61024 | 1/20 | 0.38 |
| ▸ | SKP1 | P63208 | 1/20 | 0.38 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.37 |
| ▸ | FYN | P06241 | 1/20 | 0.37 |
| ▸ | YES1 | P07947 | 1/20 | 0.37 |
| ▸ | LYN | P07948 | 1/20 | 0.37 |
| ▸ | HCK | P08631 | 1/20 | 0.37 |
| ▸ | FGR | P09769 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | FER | P16591 | 1/20 | 0.37 |
| ▸ | CSK | P41240 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19544885 | 1.00 | RET (0.40) | RETBTKKDREGFRLCK | |
| SCHEMBL19624990 | 0.91 | BTK (0.43) | BTKEGFRLCKITKCKS1B | |
| SCHEMBL19544474 | 0.91 | BTK (0.43) | BTKEGFRLCKITKCKS1B | |
| SCHEMBL19624791 | 0.91 | RET (0.42) | RETBTKKDREGFRLCK | |
| SCHEMBL19544632 | 0.89 | RET (0.41) | RETBTKKDREGFRLCK | |
| SCHEMBL19544559 | 0.83 | KMT2A (0.43) | BTKEGFRCKS1BSKP1SKP2 | |
| SCHEMBL19544714 | 0.83 | EPHX2 (0.38) | RETBTKCKS1BSKP1SKP2 | |
| SCHEMBL19544596 | 0.83 | BTK (0.51) | BTKEGFRLCKITK | |
| SCHEMBL19624800 | 0.83 | EPHX2 (0.37) | RETBTKKDREGFRLCK | |
| SCHEMBL19533591 | 0.81 | RET (0.44) | RETBTKKDREGFRLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3246317-A1 | BTK INHIBITOR | Hubei Bio-Pharmaceutical Industrial Technological Institute Inc. (CN) | 2017-11-22 | — | — | EP | disclosed |