Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 20/20 | 0.79 |
| ▸ | CCND1 | P24385 | 18/20 | 0.79 |
| ▸ | CCND2 | P30279 | 14/20 | 0.79 |
| ▸ | CCND3 | P30281 | 14/20 | 0.79 |
| ▸ | CDK2 | P24941 | 5/20 | 0.76 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.76 |
| ▸ | CDK6 | Q00534 | 4/20 | 0.76 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.76 |
| ▸ | CDK1 | P06493 | 2/20 | 0.76 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.76 |
| ▸ | FLT3 | P36888 | 2/20 | 0.76 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.76 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.76 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.76 |
| ▸ | CCNT2 | O60583 | 1/20 | 0.76 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.76 |
| ▸ | STK16 | O75716 | 1/20 | 0.76 |
| ▸ | CCNK | O75909 | 1/20 | 0.76 |
| ▸ | PDE5A | O76074 | 1/20 | 0.76 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28412630 | 0.93 | CDK4 (0.78) | CDK4CCND1CCND2CCND3CDK2 | |
| SCHEMBL4826672 | 0.88 | CDK4 (1.00) | CDK4CCND1CCND2CCND3CDK2 | |
| SCHEMBL29507539 | 0.88 | CDK4 (1.00) | CDK4CCND1CCND2CCND3CDK2 | |
| SCHEMBL29507507 | 0.88 | CDK4 (1.00) | CDK4CCND1CCND2CCND3CDK2 | |
| SCHEMBL6221577 | 0.88 | CDK4 (1.00) | CDK4CCND1CCND2CCND3CDK2 | |
| SCHEMBL28409617 | 0.88 | CDK4 (0.76) | CDK4CCND1CCND2CCND3CDK2 | |
| SCHEMBL6223801 | 0.88 | CDK4 (0.98) | CDK4CCND1CCND2CCND3CDK2 | |
| SCHEMBL15874775 | 0.87 | CDK4 (0.89) | CDK4CCND1CCND2CCND3CDK2 | |
| SCHEMBL15874369 | 0.87 | CDK4 (0.74) | CDK4CCND1CCND2CCND3CDK2 | |
| SCHEMBL4828618 | 0.86 | CDK4 (0.80) | CDK4CCND1CCND2CCND3CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4289844-A2 | A PROCESS FOR MAKING PALBOCICLIB | Synthon B.V. (NL) | 2023-12-13 | — | — | EP | disclosed |
| EP-3458604-B1 | METHOD FOR DETERMINING SENSITIVITY TO A CDK4/6 INHIBITOR | UNIV BRUXELLES (BE) | 2021-04-14 | — | — | EP | disclosed |
| WO-2017198685-A1 | METHOD FOR DETERMINING SENSITIVITY TO A CDK4/6 INHIBITOR | Université Libre de Bruxelles (BE) | 2017-11-23 | — | — | WO | disclosed |