Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 2/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.42 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.40 |
| ▸ | AXL | P30530 | 2/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL467492 | 1.00 | HTR1D (0.44) | HTR1DGRIN2BHRH3BRD4ATAD2 | |
| SCHEMBL24740684 | 0.92 | HTR1D (0.47) | HTR1DGRIN2BBRD4ATAD2L3MBTL3 | |
| SCHEMBL30300596 | 0.92 | HTR1D (0.47) | HTR1DGRIN2BBRD4ATAD2L3MBTL3 | |
| SCHEMBL24740615 | 0.90 | HTR1D (0.48) | HTR1DGRIN2BBRD4ATAD2L3MBTL3 | |
| SCHEMBL30612416 | 0.88 | GRIN2B (0.45) | HTR1DGRIN2BBRD4ATAD2 | |
| SCHEMBL29113501 | 0.88 | GRIN2B (0.45) | HTR1DGRIN2BBRD4ATAD2 | |
| SCHEMBL2060586 | 0.87 | GRIN2B (0.44) | HTR1DGRIN2BHRH3BRD4ATAD2 | |
| SCHEMBL4768314 | 0.86 | HRH3 (0.56) | HRH3CYP2D6 | |
| SCHEMBL1953271 | 0.86 | HRH3 (0.49) | GRIN2BHRH3BRD4ATAD2CYP2D6 | |
| SCHEMBL520119 | 0.85 | HRH3 (0.44) | GRIN2BHRH3BRD4ATAD2L3MBTL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024199102-A1 | METHOD FOR PREPARING AXL INHIBITOR | 南京正大天晴制药有限公司 | 2024-10-03 | — | — | WO | disclosed |
| WO-2024199100-A1 | PREPARATION METHOD FOR AXL INHIBITOR INTERMEDIATE | 南京正大天晴制药有限公司 | 2024-10-03 | — | — | WO | disclosed |
| US-20240246967-A1 | AXL COMPOUNDS | ARCUS BIOSCIENCES, INC. | 2024-07-25 | — | — | US | disclosed |
| US-20240226115-A1 | AXL INHIBITOR COMPOUNDS | ARCUS BIOSCIENCES, INC. | 2024-07-11 | — | — | US | disclosed |
| US-20240226115-A1 | AXL INHIBITOR COMPOUNDS | ARCUS BIOSCIENCES, INC. | 2024-07-11 | — | — | US | disclosed |
| US-20240226115-A1 | AXL INHIBITOR COMPOUNDS | ARCUS BIOSCIENCES, INC. | 2024-07-11 | — | — | US | disclosed |
| EP-4341261-A1 | AXL COMPOUNDS | Arcus Biosciences, Inc. (US) | 2024-03-27 | — | — | EP | disclosed |
| CN-117337288-A | AXL inhibitor compounds | 艾库斯生物科学有限公司 | 2024-01-02 | — | — | CN | disclosed |
| CN-117295741-A | AXL compounds | 艾库斯生物科学有限公司 | 2023-12-26 | — | — | CN | disclosed |
| US-20230227484-A1 | PYRIMIDINE COMPOUND AS AXL INHIBITOR | NANJING CHIA TAI TIANQING PHARMACEUTICAL CO., LTD. (CN) | 2023-07-20 | — | — | US | disclosed |
| EP-4163278-A1 | PYRIMIDINE COMPOUND AS AXL INHIBITOR | Nanjing Chia Tai Tianqing Pharmaceutical Co., Ltd. (CN) | 2023-04-12 | — | — | EP | disclosed |
| CN-115697993-A | Pyrimidines as AXL inhibitors | 南京正大天晴制药有限公司 | 2023-02-03 | — | — | CN | disclosed |
| CN-115557945-A | Triazolopyridine compounds as AXL inhibitors | 南京正大天晴制药有限公司 | 2023-01-03 | — | — | CN | disclosed |
| WO-2022246179-A1 | AXL INHIBITOR COMPOUNDS | ARCUS BIOSCIENCES, INC. (US) | 2022-11-24 | — | — | WO | disclosed |
| WO-2022246177-A1 | AXL COMPOUNDS | ARCUS BIOSCIENCES, INC. (US) | 2022-11-24 | — | — | WO | disclosed |
| WO-2021239133-A1 | PYRIMIDINE COMPOUND AS AXL INHIBITOR | 南京正大天晴制药有限公司 | 2021-12-02 | — | — | WO | disclosed |
| US-9994553-B2 | Process for the purification of the Axl tyrosine receptor kinase inhibitor “R428” | BERGENBIO AS (NO) | 2018-06-12 | — | — | US | disclosed |
| US-9994553-B2 | Process for the purification of the Axl tyrosine receptor kinase inhibitor “R428” | BERGENBIO AS (NO) | 2018-06-12 | — | — | US | disclosed |
| US-20170334884-A1 | PROCESS FOR THE PURIFICATION OF THE AXL TYROSINE RECEPTOR KINASE INHIBITOR \"R428\ | BERGENBIO ASA (NO) | 2017-11-23 | — | — | US | disclosed |
| US-20170334884-A1 | PROCESS FOR THE PURIFICATION OF THE AXL TYROSINE RECEPTOR KINASE INHIBITOR \"R428\ | BERGENBIO ASA (NO) | 2017-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170334884-A1 | PROCESS FOR THE PURIFICATION OF THE AXL TYROSINE RECEPTOR KINASE INHIBITOR \"R428\ | AXL, TYRO3, RET | HTR1D 678/4885GRIN2B 1266/4885HRH3 573/4885 |
| US-20230227484-A1 | PYRIMIDINE COMPOUND AS AXL INHIBITOR | AXL, FLT3, TYMP | HTR1D 2800/4885GRIN2B 3068/4885HRH3 2517/4885 |
| US-20240226115-A1 | AXL INHIBITOR COMPOUNDS | AXL, BTK, MERTK | HTR1D 4076/4885GRIN2B 3423/4885HRH3 2491/4885 |
| US-20240246967-A1 | AXL COMPOUNDS | AXL, FLT3, BTK | HTR1D 4086/4885GRIN2B 3348/4885HRH3 2125/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.