Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 13/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | FASN | P49327 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19633123 | 0.84 | GRM2 (1.00) | GRM2KCNH2 | |
| SCHEMBL19633012 | 0.78 | GRM2 (1.00) | GRM2KCNH2 | |
| SCHEMBL740701 | 0.72 | GRM2 (0.69) | GRM2MAPK1KCNH2 | |
| SCHEMBL16885614 | 0.68 | MAPK1 (1.00) | GRM2MAPK1 | |
| SCHEMBL19633150 | 0.68 | GRM2 (1.00) | GRM2KCNH2 | |
| SCHEMBL19632766 | 0.65 | GRM2 (0.80) | GRM2KCNH2 | |
| SCHEMBL3368134 | 0.64 | CYP3A4 (0.59) | ALDH1A1MAPTHSD17B10 | |
| SCHEMBL15257813 | 0.64 | CYP3A4 (0.59) | ALDH1A1MAPTHSD17B10 | |
| SCHEMBL21123903 | 0.64 | GRM2 (0.79) | GRM2KCNH2 | |
| SCHEMBL20836159 | 0.64 | GRM2 (0.79) | GRM2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3459948-B1 | FLUORINE-CONTAINING TRIAZOLOPYRIDINE, AND MANUFACTURING METHOD, PHARMACEUTICAL COMPOSITION, AND APPLICATION THEREOF | SHANGHAI INST MATERIA MEDICA CAS (CN) | 2021-11-17 | — | — | EP | disclosed |
| US-10800776-B2 | Fluorine-containing triazolopyridine, and manufacturing method, pharmaceutical composition, and application thereof | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2020-10-13 | — | — | US | disclosed |
| US-20190202827-A1 | FLUORINE-CONTAINING TRIAZOLOPYRIDINE, AND MANUFACTURING METHOD, PHARMACEUTICAL COMPOSITION, AND APPLICATION THEREOF | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2019-07-04 | — | — | US | disclosed |
| EP-3459948-A1 | FLUORINE-CONTAINING TRIAZOLOPYRIDINE, AND MANUFACTURING METHOD, PHARMACEUTICAL COMPOSITION, AND APPLICATION THEREOF | Shanghai Institute Of Materia Medica Chinese Academy of Sciences (CN) | 2019-03-27 | — | — | EP | disclosed |
| WO-2017198180-A1 | FLUORINE-CONTAINING TRIAZOLOPYRIDINE, AND MANUFACTURING METHOD, PHARMACEUTICAL COMPOSITION, AND APPLICATION THEREOF | 中国科学院上海药物研究所 | 2017-11-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190202827-A1 | FLUORINE-CONTAINING TRIAZOLOPYRIDINE, AND MANUFACTURING METHOD, PHARMACEUTICAL COMPOSITION, AND APPLICATION THEREOF | GRM2, GRM1, GRIK2 | GRM2 1/4885MAPK1 1048/4885KCNH2 401/4885 |
| US-10800776-B2 | Fluorine-containing triazolopyridine, and manufacturing method, pharmaceutical composition, and application thereof | GRM2, GRM1, GRIK2 | GRM2 1/4885MAPK1 1048/4885KCNH2 401/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.