Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 16/20 | 0.58 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.56 |
| ▸ | FBP1 | P09467 | 2/20 | 0.56 |
| ▸ | KDR | P35968 | 2/20 | 0.56 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.56 |
| ▸ | AURKA | O14965 | 1/20 | 0.56 |
| ▸ | INSR | P06213 | 1/20 | 0.56 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.56 |
| ▸ | FLT4 | P35916 | 1/20 | 0.56 |
| ▸ | CLK1 | P49759 | 1/20 | 0.56 |
| ▸ | TEK | Q02763 | 1/20 | 0.56 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.56 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.55 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.54 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1418092 | 0.94 | EGFR (0.65) | EGFRERBB2FBP1KDREPHB4 | |
| SCHEMBL1417822 | 0.92 | EGFR (0.65) | EGFRERBB2FBP1KDREPHB4 | |
| SCHEMBL1418427 | 0.91 | EGFR (0.64) | EGFRERBB2FBP1KDREPHB4 | |
| SCHEMBL15106827 | 0.86 | EGFR (0.58) | EGFRERBB2FBP1KDREPHB4 | |
| SCHEMBL1191094 | 0.85 | EGFR (0.68) | EGFRERBB2FBP1KDREPHB4 | |
| SCHEMBL15106917 | 0.85 | ERBB2 (0.68) | EGFRERBB2FBP1KDREPHB4 | |
| SCHEMBL7219084 | 0.84 | EGFR (0.65) | EGFRERBB2FBP1KDREPHB4 | |
| SCHEMBL1190516 | 0.84 | EGFR (0.69) | EGFRERBB2KDREPHB4EPHA2 | |
| SCHEMBL1190518 | 0.84 | EGFR (0.69) | EGFRERBB2KDREPHB4EPHA2 | |
| SCHEMBL31038407 | 0.84 | EGFR (0.69) | EGFRERBB2KDREPHB4EPHA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10507209-B2 | Quinazoline derivatives substituted by aniline, preparation method and use thereof | XUANZHU PHARMA CO, LTD. (CN) | 2019-12-17 | — | — | US | disclosed |
| US-20170333433-A1 | QUINAZOLINE DERIVATIVES SUBSTITUTED BY ANILINE, PREPARATION METHOD AND USE THEREOF | XUANZHU PHARMA CO, LTD. (CN) | 2017-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170333433-A1 | QUINAZOLINE DERIVATIVES SUBSTITUTED BY ANILINE, PREPARATION METHOD AND USE THEREOF | NQO2, CHRM1, CHRM2 | EGFR 983/4885ERBB2 1417/4885FBP1 4301/4885 |
| US-10507209-B2 | Quinazoline derivatives substituted by aniline, preparation method and use thereof | NQO2, CHRM1, CHRM2 | EGFR 983/4885ERBB2 1417/4885FBP1 4301/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.