Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN8A | Q9UQD0 | 7/20 | 0.44 |
| ▸ | SCN1A | P35498 | 6/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.36 |
| ▸ | GCK | P35557 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 3/20 | 0.34 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.34 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 2/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 2/20 | 0.32 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.32 |
| ▸ | INCENP | Q9NQS7 | 2/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19634022 | 0.80 | SCN8A (0.69) | SCN8ASCN1A | |
| SCHEMBL19634095 | 0.79 | SCN8A (0.43) | SCN8ASCN1ASCN9ACYP3A4 | |
| SCHEMBL19631804 | 0.78 | SCN8A (0.68) | SCN8ASCN1ASCN9ACYP3A4 | |
| SCHEMBL19631636 | 0.73 | SCN8A (0.63) | SCN8ASCN1ASCN9AGCKCYP3A4 | |
| Trifluoroacetic Acid SCHEMBL19614282 | 0.73 | SCN8A (0.63) | SCN8ASCN1ASCN9ACYP3A4 | |
| SCHEMBL19634021 | 0.72 | SCN8A (0.44) | SCN8ASCN1A | |
| SCHEMBL19614285 | 0.65 | SCN8A (0.41) | SCN8ASCN1ASCN9AGCKCYP3A4 | |
| SCHEMBL19633938 | 0.63 | SCN8A (0.42) | SCN8ASCN1A | |
| SCHEMBL8271730 | 0.62 | ROCK1 (0.47) | HTR1ASLC6A2SLC6A3SLC6A4 | |
| SCHEMBL19634135 | 0.61 | SCN8A (0.41) | SCN8ASCN1ASCN9ASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017201468-A1 | BENZENESULFONAMIDE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2017-11-23 | — | — | WO | disclosed |