Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.70 |
| ▸ | EPHX2 | P34913 | 13/20 | 0.56 |
| ▸ | NR1H4 | Q96RI1 | 11/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | CA7 | P43166 | 1/20 | 0.52 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | MMP13 | P45452 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21016148 | 0.85 | HDAC6 (0.67) | HDAC6EPHX2NR1H4CA1CA2 | |
| SCHEMBL21015945 | 0.84 | HDAC6 (0.65) | HDAC6EPHX2NR1H4CA1CA2 | |
| SCHEMBL21015215 | 0.83 | EPHX2 (0.54) | HDAC6EPHX2NR1H4HDAC3HDAC8 | |
| SCHEMBL19634460 | 0.83 | HDAC6 (0.63) | HDAC6EPHX2NR1H4CA1CA2 | |
| SCHEMBL21015341 | 0.83 | NR1H4 (0.52) | HDAC6NR1H4HDAC3HDAC8RAB9A | |
| SCHEMBL21015474 | 0.83 | HDAC6 (0.77) | HDAC6EPHX2NR1H4CA1CA2 | |
| SCHEMBL19634415 | 0.83 | HDAC1 (0.68) | HDAC6EPHX2NR1H4HDAC3HDAC8 | |
| SCHEMBL19634455 | 0.83 | HDAC6 (0.59) | HDAC6EPHX2NR1H4CA1CA2 | |
| SCHEMBL21015209 | 0.82 | HDAC6 (0.62) | HDAC6HDAC3HDAC8CYP2C19LMNA | |
| SCHEMBL21016156 | 0.82 | HDAC6 (0.62) | HDAC6EPHX2NR1H4CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190151403-A1 | NOVEL CYCLOSPORIN DERIVATIVES AND USES THEREOF | S&T GLOBAL INC. | 2019-05-23 | — | — | US | disclosed |
| WO-2017200984-A1 | NOVEL CYCLOSPORIN DERIVATIVES AND USES THEREOF | S&T GLOBAL INC. (US) | 2017-11-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190151403-A1 | NOVEL CYCLOSPORIN DERIVATIVES AND USES THEREOF | MALT1, MYLK2, FKBP1B | HDAC6 353/4885EPHX2 4754/4885NR1H4 1808/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.