Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 20/20 | 0.49 |
| ▸ | ALB | P02768 | 2/20 | 0.47 |
| ▸ | PMAIP1 | Q13794 | 3/20 | 0.41 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.41 |
| ▸ | BAD | Q92934 | 1/20 | 0.41 |
| ▸ | EEF2K | O00418 | 1/20 | 0.39 |
| ▸ | MARK3 | P27448 | 1/20 | 0.39 |
| ▸ | AXL | P30530 | 1/20 | 0.39 |
| ▸ | BCL6 | P41182 | 1/20 | 0.39 |
| ▸ | NEK4 | P51957 | 1/20 | 0.39 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.39 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.39 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.39 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.39 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.39 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.39 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.39 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.39 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL19615419 | 0.99 | MCL1 (0.49) | MCL1ALBPMAIP1BCL2L1BAD | |
| Hydrochloric Acid SCHEMBL29601863 | 0.99 | MCL1 (0.49) | MCL1ALBPMAIP1BCL2L1BAD | |
| SCHEMBL19634865 | 0.92 | MCL1 (0.53) | MCL1ALBPMAIP1BCL2L1BAD | |
| Hydrochloric Acid SCHEMBL29602481 | 0.92 | MCL1 (0.53) | MCL1ALBPMAIP1BCL2L1BAD | |
| Hydrochloric Acid SCHEMBL19615390 | 0.92 | MCL1 (0.53) | MCL1ALBPMAIP1BCL2L1BAD | |
| SCHEMBL19635480 | 0.91 | MCL1 (0.60) | MCL1ALBPMAIP1BCL2L1BAD | |
| Hydrochloric Acid SCHEMBL29601770 | 0.91 | MCL1 (0.59) | MCL1ALBPMAIP1BCL2L1BAD | |
| Hydrochloric Acid SCHEMBL19615290 | 0.91 | MCL1 (0.59) | MCL1ALBPMAIP1BCL2L1BAD | |
| SCHEMBL19635873 | 0.90 | MCL1 (0.53) | MCL1ALBPMAIP1BCL2L1BAD | |
| Hydrochloric Acid SCHEMBL19615873 | 0.90 | MCL1 (0.52) | MCL1ALBPMAIP1BCL2L1BAD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3458459-B1 | MACROCYCLIC INDOLE DERIVATIVES | BAYER AG (DE) | 2022-04-27 | — | — | EP | disclosed |
| US-10981932-B2 | Macrocyclic indole derivatives | BAYER AKTIENGESELLSCHAFT (DE) | 2021-04-20 | — | — | US | disclosed |
| WO-2017198341-A1 | MACROCYCLIC INDOLE DERIVATIVES | BAYER AKTIENGESELLSCHAFT (DE) | 2017-11-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10981932-B2 | Macrocyclic indole derivatives | CCND2, IDO1, CCNT2 | MCL1 62/4885ALB 2042/4885PMAIP1 1664/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.