Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 20/20 | 0.48 |
| ▸ | BCL2 | P10415 | 2/20 | 0.39 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.39 |
| ▸ | PMAIP1 | Q13794 | 6/20 | 0.37 |
| ▸ | BAD | Q92934 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19635435 | 0.91 | MCL1 (0.60) | MCL1BCL2BCL2L1PMAIP1BAD | |
| SCHEMBL24378082 | 0.90 | MCL1 (0.53) | MCL1BCL2BCL2L1PMAIP1BAD | |
| SCHEMBL19635434 | 0.89 | MCL1 (0.47) | MCL1BCL2BCL2L1PMAIP1BAD | |
| SCHEMBL19635289 | 0.83 | MCL1 (0.51) | MCL1BCL2BCL2L1PMAIP1BAD | |
| SCHEMBL19635615 | 0.82 | MCL1 (0.58) | MCL1BCL2BCL2L1PMAIP1BAD | |
| SCHEMBL19634986 | 0.81 | MCL1 (0.59) | MCL1BCL2BCL2L1BAD | |
| SCHEMBL19635022 | 0.80 | MCL1 (0.67) | MCL1BCL2BCL2L1PMAIP1BAD | |
| SCHEMBL19635436 | 0.80 | MCL1 (0.59) | MCL1BCL2BCL2L1PMAIP1BAD | |
| SCHEMBL19615363 | 0.79 | MCL1 (0.73) | MCL1BCL2BCL2L1BAD | |
| SCHEMBL19634987 | 0.78 | MCL1 (0.65) | MCL1BCL2BCL2L1BAD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3458459-B1 | MACROCYCLIC INDOLE DERIVATIVES | BAYER AG (DE) | 2022-04-27 | — | — | EP | disclosed |
| WO-2017198341-A1 | MACROCYCLIC INDOLE DERIVATIVES | BAYER AKTIENGESELLSCHAFT (DE) | 2017-11-23 | — | — | WO | disclosed |