Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 20/20 | 0.60 |
| ▸ | EEF2K | O00418 | 1/20 | 0.52 |
| ▸ | MARK3 | P27448 | 1/20 | 0.52 |
| ▸ | AXL | P30530 | 1/20 | 0.52 |
| ▸ | BCL6 | P41182 | 1/20 | 0.52 |
| ▸ | NEK4 | P51957 | 1/20 | 0.52 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.52 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.52 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.52 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.52 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.52 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.52 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.52 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.52 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.52 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.52 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19635100 | 0.94 | MCL1 (0.60) | MCL1EEF2KMARK3AXLBCL6 | |
| SCHEMBL19615836 | 0.91 | MCL1 (0.73) | MCL1EEF2KMARK3AXLBCL6 | |
| SCHEMBL19615296 | 0.88 | MCL1 (0.62) | MCL1EEF2KMARK3AXLBCL6 | |
| SCHEMBL29602090 | 0.88 | MCL1 (0.62) | MCL1EEF2KMARK3AXLBCL6 | |
| SCHEMBL19634981 | 0.88 | MCL1 (0.62) | MCL1EEF2KMARK3AXLBCL6 | |
| SCHEMBL24378104 | 0.87 | MCL1 (0.51) | MCL1EEF2KMARK3AXLBCL6 | |
| SCHEMBL19615299 | 0.86 | MCL1 (0.63) | MCL1EEF2KMARK3AXLBCL6 | |
| SCHEMBL19615293 | 0.86 | MCL1 (0.70) | MCL1EEF2KMARK3AXLBCL6 | |
| SCHEMBL19634980 | 0.86 | MCL1 (0.59) | MCL1EEF2KMARK3AXLBCL6 | |
| SCHEMBL19615115 | 0.85 | MCL1 (0.61) | MCL1EEF2KMARK3AXLBCL6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017198341-A1 | MACROCYCLIC INDOLE DERIVATIVES | BAYER AKTIENGESELLSCHAFT (DE) | 2017-11-23 | — | — | WO | disclosed |