Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 18/20 | 0.48 |
| ▸ | ALB | P02768 | 2/20 | 0.45 |
| ▸ | EEF2K | O00418 | 2/20 | 0.39 |
| ▸ | MARK3 | P27448 | 2/20 | 0.39 |
| ▸ | AXL | P30530 | 2/20 | 0.39 |
| ▸ | NEK4 | P51957 | 2/20 | 0.39 |
| ▸ | CAMK2B | Q13554 | 2/20 | 0.39 |
| ▸ | CAMK2G | Q13555 | 2/20 | 0.39 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.39 |
| ▸ | MARK2 | Q7KZI7 | 2/20 | 0.39 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.39 |
| ▸ | HIPK2 | Q9H2X6 | 2/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.39 |
| ▸ | MAP3K20 | Q9NYL2 | 2/20 | 0.39 |
| ▸ | BCL6 | P41182 | 1/20 | 0.39 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.39 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.39 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.39 |
| ▸ | PMAIP1 | Q13794 | 2/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19635776 | 0.90 | MCL1 (0.49) | MCL1ALBEEF2KMARK3AXL | |
| SCHEMBL19635234 | 0.87 | MCL1 (0.57) | MCL1ALBEEF2KMARK3AXL | |
| Hydrochloric Acid SCHEMBL19615215 | 0.86 | MCL1 (0.57) | MCL1ALBEEF2KMARK3AXL | |
| Hydrochloric Acid SCHEMBL29601856 | 0.86 | MCL1 (0.57) | MCL1ALBEEF2KMARK3AXL | |
| SCHEMBL19635235 | 0.86 | MCL1 (0.45) | MCL1ALBEEF2KMARK3AXL | |
| SCHEMBL19634901 | 0.83 | MCL1 (0.48) | MCL1ALBEEF2KMARK3AXL | |
| SCHEMBL19635841 | 0.83 | MCL1 (0.47) | MCL1ALBEEF2KMARK3AXL | |
| SCHEMBL19635450 | 0.83 | MCL1 (0.49) | MCL1ALBEEF2KMARK3AXL | |
| SCHEMBL24378049 | 0.83 | MCL1 (0.47) | MCL1ALBEEF2KMARK3AXL | |
| SCHEMBL19635847 | 0.81 | MCL1 (0.54) | MCL1ALBPMAIP1BCL2L1BAD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3458459-B1 | MACROCYCLIC INDOLE DERIVATIVES | BAYER AG (DE) | 2022-04-27 | — | — | EP | disclosed |
| WO-2017198341-A1 | MACROCYCLIC INDOLE DERIVATIVES | BAYER AKTIENGESELLSCHAFT (DE) | 2017-11-23 | — | — | WO | disclosed |