Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 13/20 | 0.44 |
| ▸ | NEK4 | P51957 | 3/20 | 0.37 |
| ▸ | CAMK2B | Q13554 | 3/20 | 0.37 |
| ▸ | CAMK2G | Q13555 | 3/20 | 0.37 |
| ▸ | CAMK2D | Q13557 | 3/20 | 0.37 |
| ▸ | HIPK2 | Q9H2X6 | 3/20 | 0.37 |
| ▸ | MAP3K20 | Q9NYL2 | 3/20 | 0.37 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.37 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.37 |
| ▸ | EEF2K | O00418 | 2/20 | 0.37 |
| ▸ | MARK3 | P27448 | 2/20 | 0.37 |
| ▸ | AXL | P30530 | 2/20 | 0.37 |
| ▸ | MARK2 | Q7KZI7 | 2/20 | 0.37 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.37 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.37 |
| ▸ | BCL6 | P41182 | 1/20 | 0.37 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29601864 | 0.86 | MCL1 (0.46) | MCL1NEK4CAMK2BCAMK2GCAMK2D | |
| SCHEMBL19635271 | 0.86 | MCL1 (0.46) | MCL1NEK4CAMK2BCAMK2GCAMK2D | |
| SCHEMBL29602509 | 0.81 | MCL1 (0.44) | MCL1NPC1RAB9AKMT2AMAPT | |
| SCHEMBL19635710 | 0.81 | MCL1 (0.44) | MCL1NPC1RAB9AKMT2AMAPT | |
| SCHEMBL21802238 | 0.78 | MCL1 (0.54) | MCL1NEK4CAMK2BCAMK2GCAMK2D | |
| SCHEMBL29601778 | 0.76 | MCL1 (0.39) | MCL1NEK4CAMK2BCAMK2GCAMK2D | |
| SCHEMBL19635268 | 0.76 | MCL1 (0.39) | MCL1NEK4CAMK2BCAMK2GCAMK2D | |
| SCHEMBL19635269 | 0.76 | MCL1 (0.39) | MCL1NEK4CAMK2BCAMK2GCAMK2D | |
| SCHEMBL19615282 | 0.73 | MCL1 (0.58) | MCL1NEK4CAMK2BCAMK2GCAMK2D | |
| SCHEMBL19615834 | 0.72 | MCL1 (0.53) | MCL1NEK4CAMK2BCAMK2GCAMK2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3458459-B1 | MACROCYCLIC INDOLE DERIVATIVES | BAYER AG (DE) | 2022-04-27 | — | — | EP | disclosed |
| WO-2017198341-A1 | MACROCYCLIC INDOLE DERIVATIVES | BAYER AKTIENGESELLSCHAFT (DE) | 2017-11-23 | — | — | WO | disclosed |