Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 11/20 | 0.58 |
| ▸ | BAD | Q92934 | 10/20 | 0.45 |
| ▸ | BCL2L1 | Q07817 | 8/20 | 0.45 |
| ▸ | BCL2 | P10415 | 6/20 | 0.45 |
| ▸ | PMAIP1 | Q13794 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24594052 | 0.94 | MCL1 (0.67) | MCL1BADBCL2L1BCL2PMAIP1 | |
| SCHEMBL19635484 | 0.92 | MCL1 (0.56) | MCL1BADBCL2L1BCL2PMAIP1 | |
| SCHEMBL19635511 | 0.87 | MCL1 (0.55) | MCL1BADBCL2L1BCL2 | |
| SCHEMBL19635487 | 0.87 | MCL1 (0.77) | MCL1BADBCL2L1BCL2PMAIP1 | |
| SCHEMBL19634949 | 0.87 | MCL1 (0.54) | MCL1BADBCL2L1BCL2PMAIP1 | |
| SCHEMBL19635406 | 0.87 | MCL1 (0.75) | MCL1BADBCL2L1BCL2PMAIP1 | |
| SCHEMBL19635859 | 0.84 | MCL1 (0.75) | MCL1BADBCL2L1BCL2 | |
| SCHEMBL19635858 | 0.84 | MCL1 (0.75) | MCL1BADBCL2L1BCL2 | |
| SCHEMBL19635909 | 0.84 | MCL1 (0.55) | MCL1BADBCL2L1BCL2PMAIP1 | |
| SCHEMBL19635655 | 0.83 | MCL1 (0.63) | MCL1BADBCL2L1BCL2PMAIP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3458459-B1 | MACROCYCLIC INDOLE DERIVATIVES | BAYER AG (DE) | 2022-04-27 | — | — | EP | disclosed |
| WO-2017198341-A1 | MACROCYCLIC INDOLE DERIVATIVES | BAYER AKTIENGESELLSCHAFT (DE) | 2017-11-23 | — | — | WO | disclosed |