N-Methylhistamine

N-Methylhistamine

SCHEMBL196356

Cn1cnc(CCN)c1

nearest known ligand 0.00

Full drug profile on Sugi Atlas →

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
N-Methylhistamine SCHEMBL27340947 1.00
N-Methylhistamine SCHEMBL19951025 0.98 HRH4 (0.96)
N-Methylhistamine SCHEMBL2183879 0.98 TDP1 (1.00)
N-Methylhistamine SCHEMBL1320841 0.98 TDP1 (1.00)
SCHEMBL14416066 0.88 CYP2C9 (0.78)
N-Methylhistamine SCHEMBL25277752 0.83 CYP2C9 (0.70)
N-Methylhistamine SCHEMBL20359327 0.82 HRH4 (0.68)
SCHEMBL246132 0.82
Hydrochloric Acid SCHEMBL17835480 0.80
SCHEMBL8288760 0.80

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1014 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12584924-B2 Compositions and methods for diagnosing and treating chronic kidney disease SOCIETE DES PRODUITS NESTLE S.A. (CH) 2026-03-24 US claimed
US-20260076944-A1 COMPOSITIONS AND METHODS FOR PROMOTING BRAIN HEALTH UNIV CALIFORNIA (US) 2026-03-19 US claimed
EP-4695602-A1 METHODS OF DETECTING OVER-IMMUNOSUPPRESSION AND UNDER- IMMUNOSUPPRESSION IN RENAL TRANSPLANT RECIPIENTS Olaris, Inc. (US) 2026-02-18 EP claimed
WO-2025085668-A9 METHODS OF DETECTING OVER-IMMUNOSUPPRESSION AND UNDER- IMMUNOSUPPRESSION IN RENAL TRANSPLANT RECIPIENTS Olaris, Inc. (US) 2025-07-17 WO claimed
WO-2025085668-A1 METHODS OF DETECTING OVER-IMMUNOSUPPRESSION AND UNDER- IMMUNOSUPPRESSION IN RENAL TRANSPLANT RECIPIENTS Olaris, Inc. (US) 2025-04-24 WO claimed
EP-4457513-A1 COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING CHRONIC KIDNEY DISEASE Société des Produits Nestlé S.A. (CH) 2024-11-06 EP claimed
US-20240277668-A1 HISTAMINE RECEPTOR AGONISTS FOR CANCER THERAPY IN CANCER PATIENTS UNRESPONSIVE TO CANCER IMMUNOTHERAPY AND WITH ELEVATED MYELOID DERIVED SUPPRESSOR CELLS TSP THERAPEUTICS INC. 2024-08-22 US claimed
CN-118435054-A Compositions and methods for diagnosing and treating chronic kidney disease 雀巢产品有限公司 2024-08-02 CN claimed
EP-4376835-A1 HISTAMINE RECEPTOR AGONISTS FOR CANCER THERAPY IN CANCER PATIENTS UNRESPONSIVE TO CANCER IMMUNOTHERAPY AND WITH ELEVATED MYELOID DERIVED SUPPRESSOR CELLS TSP Therapeutics Inc. (US) 2024-06-05 EP claimed
US-20240165082-A1 ORALLY ADMINISTERED COMPOSITIONS FOR CANCER TREATMENT TSP THERAPEUTICS INC. 2024-05-23 US claimed
EP-0946744-B1 NOVEL POLYMERIC COMPLEXES FOR THE TRANSFECTION OF NUCLEIC ACIDS, WITH RESIDUES CAUSING THE DESTABILISATION OF CELL MEMBRANES IDM IMMUNO DESIGNED MOLECULES (FR) 2004-08-18 EP claimed
EP-1135481-B1 NEW OLIGOMERIC CONJUGATES LIABLE TO TRANSFER BIOLOGICAL MOLECULES INTO CELLS IDM IMMUNO DESIGNED MOLECULES (FR) 2004-02-25 EP claimed
US-20030113309-A1 Method for treatment of neurodegenerative diseases and effects of aging EAD, LLC. 2003-06-19 US claimed
US-20030082238-A1 Matrices for drug delivery and methods for making and using the same BABICH JOHN W (US) 2003-05-01 US claimed
EP-1277477-A2 Treatment of neurodegenerative diseases and the effects of aging Delack, Elaine A. (US) 2003-01-22 EP claimed
US-6395299-B1 PARKINSON'S DISEASE BIOSTREAM, INC. 2002-05-28 US claimed
WO-2000047236-A1 MATRICES FOR DRUG DELIVERY AND METHODS FOR MAKING AND USING THE SAME BIOSTREAM, INC. (US) 2000-08-17 WO claimed
EP-0214058-B1 PHARMACEUTICAL COMPOSITION CONTAINING HISTAMINE DERIVATIVES INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) 1992-05-06 EP claimed
EP-0209586-A1 ANTI-HISTAMINE ANTIBODY PREPARATION WITH SPECIFICITY FOR A 4-(2-AMINOETHYL)IMIDAZOLYL GROUP ATTACHED DIRECTLY TO AN ALKYLENE CHAIN AND IMMUNOASSAY METHOD EMPLOYING THE PREPARATION. PHARMACIA AB (SE) 1987-01-28 EP claimed
WO-1986004420-A1 ANTIBODY PREPARATION WITH SPECIFICITY FOR ALIPHATICALLY BOUND 4-(2-AMINOETHYL)IMIDAZOLYL GROUP, MANUFACTURE AND USE OF THE ANTIBODY PREPARATION PHARMACIA AB (SE) 1986-07-31 WO claimed