Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 6/20 | 0.59 |
| ▸ | BTK | Q06187 | 14/20 | 0.59 |
| ▸ | LCK | P06239 | 2/20 | 0.59 |
| ▸ | LYN | P07948 | 1/20 | 0.59 |
| ▸ | NUDT14 | O95848 | 1/20 | 0.55 |
| ▸ | NUDT5 | Q9UKK9 | 1/20 | 0.55 |
| ▸ | ABL1 | P00519 | 4/20 | 0.54 |
| ▸ | KDR | P35968 | 4/20 | 0.54 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.54 |
| ▸ | EGFR | P00533 | 3/20 | 0.54 |
| ▸ | HCK | P08631 | 3/20 | 0.54 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.54 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.54 |
| ▸ | MTOR | P42345 | 3/20 | 0.54 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.54 |
| ▸ | EPHB4 | P54760 | 3/20 | 0.54 |
| ▸ | PRKDC | P78527 | 3/20 | 0.54 |
| ▸ | PI4KB | Q9UBF8 | 3/20 | 0.54 |
| ▸ | TEK | Q02763 | 1/20 | 0.52 |
| ▸ | BLK | P51451 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30416088 | 0.87 | BTK (0.66) | SRCBTKLCKLYNNUDT14 | |
| SCHEMBL24197239 | 0.87 | BTK (0.66) | SRCBTKLCKLYNNUDT14 | |
| SCHEMBL13020215 | 0.86 | ABL1 (0.68) | SRCBTKLCKLYNABL1 | |
| SCHEMBL19635663 | 0.86 | JAK2 (0.59) | SRCBTKLCKLYNNUDT14 | |
| SCHEMBL19635667 | 0.84 | BTK (0.56) | BTKLCKLYNNUDT14NUDT5 | |
| SCHEMBL5801169 | 0.84 | BTK (0.82) | SRCBTKLCKLYNNUDT14 | |
| SCHEMBL19635798 | 0.83 | BTK (0.61) | BTKLCKLYNNUDT14NUDT5 | |
| SCHEMBL19635793 | 0.83 | BTK (0.61) | BTKLCKLYNNUDT14NUDT5 | |
| SCHEMBL19635799 | 0.83 | BTK (0.61) | BTKLCKLYNNUDT14NUDT5 | |
| SCHEMBL24196604 | 0.83 | BTK (0.68) | SRCBTKLCKLYNNUDT14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017198049-A1 | PYRAZOLOPYRIMIDINE DERIVATIVE AS BTK INHIBITOR AND PREPARATION METHOD AND PHARMACEUTICAL COMPOSITION THEREOF | 浙江予川医药科技有限公司 | 2017-11-23 | — | — | WO | disclosed |