Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 17/20 | 0.66 |
| ▸ | PRKCD | Q05655 | 4/20 | 0.53 |
| ▸ | CAMK2B | Q13554 | 4/20 | 0.53 |
| ▸ | CAMK2G | Q13555 | 4/20 | 0.53 |
| ▸ | NEK4 | P51957 | 3/20 | 0.53 |
| ▸ | CAMK2D | Q13557 | 3/20 | 0.53 |
| ▸ | HIPK2 | Q9H2X6 | 3/20 | 0.53 |
| ▸ | MAP3K20 | Q9NYL2 | 3/20 | 0.53 |
| ▸ | MAP4K5 | Q9Y4K4 | 3/20 | 0.53 |
| ▸ | MARK3 | P27448 | 2/20 | 0.53 |
| ▸ | AXL | P30530 | 2/20 | 0.53 |
| ▸ | MARK2 | Q7KZI7 | 2/20 | 0.53 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.53 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.53 |
| ▸ | EEF2K | O00418 | 1/20 | 0.53 |
| ▸ | BCL6 | P41182 | 1/20 | 0.53 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.53 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.51 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.51 |
| ▸ | CDC42BPA | Q5VT25 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4173637 | 0.85 | MCL1 (0.71) | MCL1PRKCDCAMK2BCAMK2GNEK4 | |
| SCHEMBL19615313 | 0.84 | MCL1 (0.60) | MCL1PRKCDCAMK2BCAMK2GNEK4 | |
| SCHEMBL4176427 | 0.84 | MCL1 (0.84) | MCL1PRKCDCAMK2BCAMK2GNEK4 | |
| SCHEMBL19615272 | 0.83 | MCL1 (0.60) | MCL1PRKCDCAMK2BCAMK2GNEK4 | |
| SCHEMBL4171513 | 0.82 | MCL1 (0.62) | MCL1PRKCDCAMK2BCAMK2GNEK4 | |
| SCHEMBL4165286 | 0.82 | MCL1 (0.60) | MCL1PRKCDCAMK2BCAMK2GNEK4 | |
| SCHEMBL4165283 | 0.81 | MCL1 (0.83) | MCL1PRKCDCAMK2BCAMK2GNEK4 | |
| SCHEMBL4168695 | 0.81 | MCL1 (0.59) | MCL1PRKCDCAMK2BCAMK2GNEK4 | |
| SCHEMBL4159352 | 0.81 | MCL1 (0.85) | MCL1PRKCDCAMK2BCAMK2GNEK4 | |
| SCHEMBL4165028 | 0.81 | MCL1 (0.58) | MCL1PRKCDCAMK2BCAMK2GNEK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11492358-B1 | Macrocyclic indole derivatives | THE BROAD INSTITUTE, INC. (US) | 2022-11-08 | — | — | US | disclosed |
| EP-3458459-B1 | MACROCYCLIC INDOLE DERIVATIVES | BAYER AG (DE) | 2022-04-27 | — | — | EP | disclosed |
| EP-3458459-B1 | MACROCYCLIC INDOLE DERIVATIVES | BAYER AG (DE) | 2022-04-27 | — | — | EP | disclosed |
| CN-109715632-B | Macrocyclic indole derivatives | 拜尔公开股份有限公司 | 2021-10-26 | — | — | CN | disclosed |
| US-10981932-B2 | Macrocyclic indole derivatives | BAYER AKTIENGESELLSCHAFT (DE) | 2021-04-20 | — | — | US | disclosed |
| US-10981932-B2 | Macrocyclic indole derivatives | BAYER AKTIENGESELLSCHAFT (DE) | 2021-04-20 | — | — | US | disclosed |
| US-20200087322-A1 | MACROCYCLIC INDOLE DERIVATIVES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2020-03-19 | — | — | US | disclosed |
| WO-2017198341-A1 | MACROCYCLIC INDOLE DERIVATIVES | BAYER AKTIENGESELLSCHAFT (DE) | 2017-11-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11492358-B1 | Macrocyclic indole derivatives | CCND2, CCNT2, IDO1 | MCL1 54/4885PRKCD 1885/4885CAMK2B 895/4885 |
| US-10981932-B2 | Macrocyclic indole derivatives | CCND2, IDO1, CCNT2 | MCL1 62/4885PRKCD 1277/4885CAMK2B 993/4885 |
| US-20200087322-A1 | MACROCYCLIC INDOLE DERIVATIVES | CCND2, CCNA1, CCNT2 | MCL1 56/4885PRKCD 1854/4885CAMK2B 965/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.