Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 20/20 | 0.55 |
| ▸ | PMAIP1 | Q13794 | 6/20 | 0.52 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.52 |
| ▸ | BAD | Q92934 | 1/20 | 0.52 |
| ▸ | BCL2 | P10415 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL21802264 | 0.89 | MCL1 (0.56) | MCL1PMAIP1BCL2L1BADBCL2 | |
| SCHEMBL21802265 | 0.88 | MCL1 (0.57) | MCL1PMAIP1BCL2L1BADBCL2 | |
| SCHEMBL19635028 | 0.88 | MCL1 (0.64) | MCL1PMAIP1BCL2L1BADBCL2 | |
| SCHEMBL19635600 | 0.86 | MCL1 (0.56) | MCL1PMAIP1BCL2L1BADBCL2 | |
| SCHEMBL19635395 | 0.86 | MCL1 (0.52) | MCL1PMAIP1BCL2L1BADBCL2 | |
| SCHEMBL19635339 | 0.86 | MCL1 (0.66) | MCL1BCL2L1BADBCL2 | |
| SCHEMBL19615195 | 0.84 | MCL1 (0.67) | MCL1PMAIP1BCL2L1BADBCL2 | |
| SCHEMBL19635675 | 0.84 | MCL1 (0.68) | MCL1PMAIP1BCL2L1BADBCL2 | |
| SCHEMBL19635594 | 0.84 | MCL1 (0.61) | MCL1BCL2L1BADBCL2 | |
| SCHEMBL19635264 | 0.84 | MCL1 (0.63) | MCL1PMAIP1BCL2L1BADBCL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3458459-B1 | MACROCYCLIC INDOLE DERIVATIVES | BAYER AG (DE) | 2022-04-27 | — | — | EP | disclosed |
| WO-2017198341-A1 | MACROCYCLIC INDOLE DERIVATIVES | BAYER AKTIENGESELLSCHAFT (DE) | 2017-11-23 | — | — | WO | disclosed |