Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 20/20 | 0.51 |
| ▸ | VHL | P40337 | 1/20 | 0.40 |
| ▸ | CDK7 | P50613 | 1/20 | 0.40 |
| ▸ | CCNH | P51946 | 1/20 | 0.40 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.40 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19617159 | 0.89 | KRAS (0.48) | KRASVHLCDK7CCNHMNAT1 | |
| SCHEMBL19948362 | 0.88 | KRAS (0.51) | KRASVHLCDK7CCNHMNAT1 | |
| SCHEMBL19948347 | 0.88 | KRAS (0.51) | KRASVHLCDK7CCNHMNAT1 | |
| SCHEMBL30188783 | 0.88 | KRAS (0.51) | KRASVHLCDK7CCNHMNAT1 | |
| SCHEMBL28519725 | 0.86 | KRAS (0.51) | KRASVHLCDK7CCNHMNAT1 | |
| SCHEMBL19616800 | 0.86 | KRAS (0.55) | KRASVHLCDK7CCNHMNAT1 | |
| SCHEMBL19616796 | 0.86 | KRAS (0.55) | KRASVHLCDK7CCNHMNAT1 | |
| SCHEMBL25020018 | 0.86 | KRAS (0.42) | KRASVHLCDK7CCNHMNAT1 | |
| SCHEMBL19636822 | 0.85 | KRAS (0.46) | KRASVHLCDK7CCNHMNAT1 | |
| SCHEMBL24276561 | 0.85 | KRAS (0.46) | KRASVHLCDK7CCNHMNAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3710439-B1 | KRAS G12C INHIBITORS | MIRATI THERAPEUTICS INC (US) | 2023-02-15 | — | — | EP | disclosed |
| WO-2017201161-A1 | KRAS G12C INHIBITORS | Mirati Therapeutics, Inc. (US) | 2017-11-23 | — | — | WO | disclosed |