Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 20/20 | 0.69 |
| ▸ | VHL | P40337 | 1/20 | 0.50 |
| ▸ | CDK7 | P50613 | 1/20 | 0.50 |
| ▸ | CCNH | P51946 | 1/20 | 0.50 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.50 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19637419 | 0.95 | KRAS (0.68) | KRASVHLCDK7CCNHMNAT1 | |
| SCHEMBL24788038 | 0.92 | KRAS (0.78) | KRASVHLCDK7CCNHMNAT1 | |
| SCHEMBL19636883 | 0.92 | KRAS (0.78) | KRASVHLCDK7CCNHMNAT1 | |
| SCHEMBL25020006 | 0.91 | KRAS (0.67) | KRASVHLCDK7CCNHMNAT1 | |
| SCHEMBL25020955 | 0.90 | KRAS (0.68) | KRASVHLCDK7CCNHMNAT1 | |
| SCHEMBL19948207 | 0.89 | KRAS (0.87) | KRASVHLCDK7CCNHMNAT1 | |
| SCHEMBL19637317 | 0.88 | KRAS (0.64) | KRASVHLCDK7CCNHMNAT1 | |
| SCHEMBL19637381 | 0.88 | KRAS (0.68) | KRASVHLCDK7CCNHMNAT1 | |
| SCHEMBL19637319 | 0.87 | KRAS (0.69) | KRAS | |
| SCHEMBL19636889 | 0.87 | KRAS (0.69) | KRASVHLCDK7CCNHMNAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3458445-B1 | KRAS G12C INHIBITORS | MIRATI THERAPEUTICS INC (US) | 2021-02-17 | — | — | EP | disclosed |
| WO-2017201161-A1 | KRAS G12C INHIBITORS | Mirati Therapeutics, Inc. (US) | 2017-11-23 | — | — | WO | disclosed |