SCHEMBL19642886

SCHEMBL19642886

O=C(C=Cc1ccc(F)cc1)Oc1cccc2cccc(OC(=O)c3ccccc3)c12

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 9/20 0.50
LMNA P02545 3/20 0.50
MEN1 O00255 3/20 0.50
HTT P42858 2/20 0.50
L3MBTL1 Q9Y468 1/20 0.50
PLA2G7 Q13093 1/20 0.50
NPSR1 Q6W5P4 1/20 0.50
ESR1 P03372 1/20 0.47
ESR2 Q92731 1/20 0.47
METAP2 P50579 1/20 0.43
METAP1 P53582 1/20 0.43
HDAC6 Q9UBN7 1/20 0.43
GAA P10253 2/20 0.41
KDM4E B2RXH2 1/20 0.41
MAPT P10636 4/20 0.41
SMN1; SMN2 Q16637 3/20 0.41
TNFRSF1A P19438 1/20 0.41
RAB9A P51151 3/20 0.41
NPC1 O15118 2/20 0.41
NFKB1 P19838 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30712745 1.00 KMT2A (0.50) KMT2ALMNAMEN1HTTL3MBTL1
SCHEMBL19642885 1.00 KMT2A (0.50) KMT2ALMNAMEN1HTTL3MBTL1
SCHEMBL19642860 0.92 KMT2A (0.57) KMT2ALMNAMEN1HTTL3MBTL1
SCHEMBL19642861 0.92 KMT2A (0.57) KMT2ALMNAMEN1HTTL3MBTL1
SCHEMBL29563914 0.90 KMT2A (0.52) KMT2ALMNAMEN1HTTL3MBTL1
SCHEMBL19656162 0.90 KMT2A (0.52) KMT2ALMNAMEN1HTTL3MBTL1
SCHEMBL19642963 0.85 KMT2A (0.53) KMT2ALMNAMEN1HTTL3MBTL1
SCHEMBL19656082 0.85 KMT2A (0.53) KMT2ALMNAMEN1HTTL3MBTL1
SCHEMBL29563665 0.85 KMT2A (0.53) KMT2ALMNAMEN1HTTL3MBTL1
SCHEMBL19642829 0.84 MAPT (0.47) KMT2ALMNAMEN1HTTL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20200223958-A1 NON-PHTHALATE DONOR FOR POLYOLEFIN CATALYSTS W.R. GRACE & CO.-CONN. (US) 2020-07-16 US claimed
US-20190270831-A1 NON-PHTHALATE DONOR FOR POLYOLEFIN CATALYSTS W. R. GRACE & CO. - CONN. 2019-09-05 US claimed
EP-3464391-A1 NON-PHTHALATE DONOR FOR POLYOLEFIN CATALYSTS W.R. Grace & Co.-Conn. (US) 2019-04-10 EP claimed
WO-2017204811-A1 NON-PHTHALATE DONOR FOR POLYOLEFIN CATALYSTS W.R. GRACE & CO. -CONN. (US) 2017-11-30 WO claimed
EP-3464391-B1 NON-PHTHALATE DONOR FOR POLYOLEFIN CATALYSTS BRASKEM AMERICA INC (US) 2024-01-03 EP disclosed
US-11370854-B2 Non-phthalate donor for polyolefin catalysts BRASKEM AMERICA, INC. (US) 2022-06-28 US disclosed
US-11291981-B2 Boron-based electron donors for Ziegler-Natta catalyst systems BRASKEM AMERICA, INC. (US) 2022-04-05 US disclosed
US-20200223958-A1 NON-PHTHALATE DONOR FOR POLYOLEFIN CATALYSTS W.R. GRACE & CO.-CONN. (US) 2020-07-16 US disclosed
US-10662267-B2 Non-phthalate donor for polyolefin catalysts W.R. GRACE & CO. -CONN. (US) 2020-05-26 US disclosed
US-20190270831-A1 NON-PHTHALATE DONOR FOR POLYOLEFIN CATALYSTS W. R. GRACE & CO. - CONN. 2019-09-05 US disclosed
EP-3464391-A1 NON-PHTHALATE DONOR FOR POLYOLEFIN CATALYSTS W.R. Grace & Co.-Conn. (US) 2019-04-10 EP disclosed
US-20190046965-A1 BORON-BASED ELECTRON DONORS FOR ZIEGLER-NATTA CATALYST SYSTEMS BRASKEM AMERICA, INC. 2019-02-14 US disclosed
WO-2017204811-A1 NON-PHTHALATE DONOR FOR POLYOLEFIN CATALYSTS W.R. GRACE & CO. -CONN. (US) 2017-11-30 WO disclosed