Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 9/20 | 0.42 |
| ▸ | SIRT1 | Q96EB6 | 7/20 | 0.42 |
| ▸ | SIRT3 | Q9NTG7 | 3/20 | 0.42 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.41 |
| ▸ | NPY1R | P25929 | 2/20 | 0.40 |
| ▸ | NPY2R | P49146 | 2/20 | 0.40 |
| ▸ | NPY4R | P50391 | 2/20 | 0.40 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.40 |
| ▸ | FURIN | P09958 | 2/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17722897 | 0.94 | SIRT2 (0.42) | SIRT2SIRT1SIRT3SIRT5NPY1R | |
| SCHEMBL17815434 | 0.94 | SIRT2 (0.42) | SIRT2SIRT1SIRT3SIRT5NPY1R | |
| SCHEMBL18908994 | 0.94 | SIRT2 (0.42) | SIRT2SIRT1SIRT3SIRT5NPY1R | |
| SCHEMBL25094717 | 0.94 | SIRT2 (0.42) | SIRT2SIRT1SIRT3SIRT5NPY1R | |
| SCHEMBL19705471 | 0.94 | SIRT2 (0.42) | SIRT2SIRT1SIRT3SIRT5NPY1R | |
| SCHEMBL24164488 | 0.94 | SIRT2 (0.42) | SIRT2SIRT1SIRT3SIRT5NPY1R | |
| SCHEMBL22910731 | 0.94 | SIRT2 (0.42) | SIRT2SIRT1SIRT3SIRT5NPY1R | |
| SCHEMBL22643617 | 0.94 | SIRT2 (0.42) | SIRT2SIRT1SIRT3SIRT5NPY1R | |
| SCHEMBL21008370 | 0.94 | SIRT2 (0.42) | SIRT2SIRT1SIRT3SIRT5NPY1R | |
| SCHEMBL19708927 | 0.94 | SIRT2 (0.41) | SIRT2SIRT1SIRT3SIRT5NPY1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2780039-B1 | CYTOTOXIC PEPTIDES AND ANTIBODY DRUG CONJUGATES THEREOF | PFIZER (US) | 2017-11-29 | — | — | EP | disclosed |