Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPRB | P23467 | 16/20 | 0.74 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | LDHA | P00338 | 1/20 | 0.34 |
| ▸ | LDHB | P07195 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20060148 | 0.92 | PTPRB (0.72) | PTPRBCTSKMEN1NPC1RAB9A | |
| SCHEMBL468105 | 0.85 | PTPRB (1.00) | PTPRB | |
| SCHEMBL468103 | 0.85 | PTPRB (1.00) | PTPRB | |
| SCHEMBL24319137 | 0.85 | PTPRB (0.75) | PTPRBCTSKLDHALDHBMEN1 | |
| SCHEMBL19775423 | 0.83 | PTPRB (0.55) | PTPRBLMNAMAPTMEN1NPC1 | |
| SCHEMBL23770353 | 0.83 | PTPRB (0.59) | PTPRBCTSK | |
| SCHEMBL500260 | 0.83 | PTPRB (0.69) | PTPRBLMNAMAPTHTTMEN1 | |
| SCHEMBL500261 | 0.83 | PTPRB (0.69) | PTPRBLMNAMAPTHTTMEN1 | |
| SCHEMBL19775519 | 0.81 | PTPRB (0.53) | PTPRBCTSK | |
| SCHEMBL20059851 | 0.80 | PTPRB (0.51) | PTPRBLMNAMAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3977994-A1 | ACTIVATORS OF TIE-2 FOR USE IN TREATING INTRAOCULAR PRESSURE | Aerpio Pharmaceuticals, Inc. (US) | 2022-04-06 | — | — | EP | disclosed |
| EP-3352856-B1 | ACTIVATORS OF TIE-2 FOR USE IN TREATING INTRAOCULAR PRESSURE | AERPIO PHARMACEUTICALS INC (US) | 2021-08-18 | — | — | EP | disclosed |
| EP-2967066-B1 | COMPOSITIONS, FORMULATIONS AND METHODS FOR TREATING OCULAR DISEASES | AERPIO THERAPEUTICS INC (US) | 2019-10-23 | — | — | EP | disclosed |
| EP-2803663-B1 | Human protein tyrosine phosphatase inhibitors and their pharmaceutical use | AERPIO THERAPEUTICS INC (US) | 2017-11-29 | — | — | EP | disclosed |