Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 16/20 | 0.66 |
| ▸ | TYK2 | P29597 | 15/20 | 0.66 |
| ▸ | JAK2 | O60674 | 15/20 | 0.66 |
| ▸ | JAK3 | P52333 | 10/20 | 0.66 |
| ▸ | KDR | P35968 | 4/20 | 0.53 |
| ▸ | EGFR | P00533 | 1/20 | 0.53 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.48 |
| ▸ | ABL1 | P00519 | 2/20 | 0.48 |
| ▸ | STAT3 | P40763 | 2/20 | 0.48 |
| ▸ | GSK3B | P49841 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24276448 | 0.79 | TYK2 (0.55) | JAK1TYK2JAK2JAK3KDR | |
| SCHEMBL17545404 | 0.78 | TYK2 (0.63) | JAK1TYK2JAK2JAK3KDR | |
| SCHEMBL19649844 | 0.78 | TYK2 (0.63) | JAK1TYK2JAK2JAK3KDR | |
| Hydrochloric Acid SCHEMBL29414190 | 0.78 | TYK2 (0.54) | JAK1TYK2JAK2JAK3KDR | |
| Hydrochloric Acid SCHEMBL17512529 | 0.77 | TYK2 (0.62) | JAK1TYK2JAK2JAK3KDR | |
| Hydrochloric Acid SCHEMBL17512615 | 0.77 | TYK2 (0.62) | JAK1TYK2JAK2JAK3KDR | |
| SCHEMBL22856273 | 0.75 | JAK1 (0.64) | JAK1TYK2JAK2JAK3KDR | |
| SCHEMBL29414156 | 0.75 | TYK2 (0.54) | JAK1TYK2JAK2JAK3KDR | |
| SCHEMBL19649881 | 0.75 | TYK2 (0.57) | JAK1TYK2JAK2JAK3KDR | |
| SCHEMBL22567263 | 0.74 | TYK2 (0.53) | JAK1TYK2JAK2JAK3KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3183247-B9 | AMINOPYRIMIDINYL COMPOUNDS AS JAK INHIBITORS | PFIZER (US) | 2018-07-25 | — | — | EP | disclosed |
| EP-3183247-B1 | AMINOPYRIMIDINYL COMPOUNDS AS JAK INHIBITORS | PFIZER (US) | 2017-11-29 | — | — | EP | disclosed |