Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7856175 | 0.53 | — | — | |
| SCHEMBL9195226 | 0.53 | — | — | |
| SCHEMBL14881013 | 0.53 | — | — | |
| SCHEMBL18755168 | 0.53 | GABRR1 (0.31) | — | |
| SCHEMBL16609986 | 0.53 | — | — | |
| Terephthalamide SCHEMBL197479 | 0.49 | PARP1 (0.60) | ALDH1A1MAPTKMT2A | |
| SCHEMBL14185497 | 0.49 | GABRR1 (0.36) | MAPT | |
| Terephthalamide SCHEMBL12613686 | 0.49 | PARP1 (0.60) | ALDH1A1MAPTKMT2A | |
| SCHEMBL17774953 | 0.49 | IKBKB (0.40) | MEN1ALDH1A1MAPTMAPK1KMT2A | |
| SCHEMBL6181512 | 0.49 | F2 (0.71) | MEN1ALDH1A1MAPTMAPK1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2334671-A1 | CYCLOPENTATHIOPHENE MODULATORS OF THE GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-KAPPA B ACTIVITY AND USE THEREOF | Bristol-Myers Squibb Company (US) | 2011-06-22 | — | — | EP | disclosed |
| WO-2009158380-A1 | CYCLOPENTATHIOPHENE MODULATORS OF THE GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-KAPPA B ACTIVITY AND USE THEREOF | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-12-30 | — | — | WO | disclosed |