Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CACNA1B | Q00975 | 3/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.33 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | PPARA | Q07869 | 1/20 | 0.32 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.32 |
| ▸ | KLK7 | P49862 | 1/20 | 0.32 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.31 |
| ▸ | CDC25B | P30305 | 4/20 | 0.31 |
| ▸ | PTPN2 | P17706 | 3/20 | 0.31 |
| ▸ | CDC25A | P30304 | 2/20 | 0.31 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.31 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | NT5E | P21589 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL835719 | 0.88 | POLB (0.46) | POLBABL1RIN1MEN1KMT2A | |
| SCHEMBL838369 | 0.88 | POLB (0.38) | POLBABL1RIN1MEN1KMT2A | |
| SCHEMBL10095143 | 0.83 | POLB (0.39) | POLBCACNA1BABL1RIN1EGLN2 | |
| SCHEMBL10095190 | 0.81 | POLB (0.43) | POLBABL1RIN1EGLN2KLK7 | |
| SCHEMBL837720 | 0.81 | POLB (0.43) | POLBABL1RIN1EGLN2KLK7 | |
| SCHEMBL4704897 | 0.80 | POLB (0.38) | POLBABL1RIN1NT5EP2RY6 | |
| SCHEMBL12197787 | 0.73 | POLB (0.40) | POLBABL1RIN1NT5EP2RY6 | |
| SCHEMBL837389 | 0.73 | POLB (0.40) | POLBABL1RIN1NT5EP2RY6 | |
| SCHEMBL837609 | 0.72 | POLB (0.38) | POLBCACNA1BABL1RIN1MEN1 | |
| SCHEMBL10095196 | 0.72 | POLB (0.39) | POLBABL1RIN1NT5EP2RY6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899352-B1 | 1- [2' , 3' -DIDEOXY-3' C- (HYDROXYMETHYL) - BETA-D-ERYTHRO-PENTOFURANOSYL] CYTOSINE DERIVATIVES AS HIV INHIBITORS | MEDIVIR AB (SE) | 2011-10-05 | — | — | EP | disclosed |
| EP-2336135-A2 | 1-[2',3'-dideoxy-3'c-(hydroxymethyl)- beta-d-erythro-pentofuranosyl]cytosine derivatives as HIV inhibitors | Medivir AB (SE) | 2011-06-22 | — | — | EP | disclosed |