Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.46 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | TAF1 | P21675 | 1/20 | 0.45 |
| ▸ | CECR2 | Q9BXF3 | 1/20 | 0.45 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19657124 | 0.84 | BRD4 (0.47) | HSP90AA1HSP90AB1BRD4TAF1CECR2 | |
| SCHEMBL19651854 | 0.81 | HSP90AA1 (0.46) | HSP90AA1HSP90AB1BRD4TAF1CECR2 | |
| SCHEMBL19651815 | 0.77 | HSP90AA1 (0.47) | HSP90AA1HSP90AB1ATMRXFP1HTT | |
| SCHEMBL19651819 | 0.72 | MAPT (0.54) | HSP90AA1HSP90AB1ATMRXFP1HTT | |
| SCHEMBL19651856 | 0.71 | HSP90AB1 (0.46) | HSP90AA1HSP90AB1BRD4TAF1CECR2 | |
| SCHEMBL19651852 | 0.71 | BRD4 (0.48) | HSP90AA1HSP90AB1BRD4TAF1CECR2 | |
| SCHEMBL14200335 | 0.70 | HSP90AA1 (0.58) | HSP90AA1HSP90AB1HTTALDH1A1KMT2A | |
| SCHEMBL487556 | 0.70 | HSP90AA1 (0.64) | HSP90AA1HSP90AB1ATMRXFP1HTT | |
| SCHEMBL12545691 | 0.70 | HSP90AA1 (0.53) | HSP90AA1HSP90AB1ATMRXFP1HTT | |
| SCHEMBL12546090 | 0.69 | KDM4E (0.68) | HSP90AA1HSP90AB1ATMRXFP1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10183009-B2 | Therapeutic compounds and uses thereof | GENENTECH, INC. (US) | 2019-01-22 | — | — | US | disclosed |
| US-20170340605-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2017-11-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10183009-B2 | Therapeutic compounds and uses thereof | BRD4, BRDT, BRPF3 | HSP90AA1 1632/4885HSP90AB1 1054/4885BRD4 1/4885 |
| US-20170340605-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | BRD4, BRDT, BRPF3 | HSP90AA1 1632/4885HSP90AB1 1054/4885BRD4 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.