⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10562763 | 1.00 | — | — | |
| SCHEMBL337169 | 1.00 | — | — | |
| SCHEMBL15933364 | 0.79 | — | — | |
| SCHEMBL3079450 | 0.79 | — | — | |
| SCHEMBL3079453 | 0.79 | — | — | |
| SCHEMBL31531965 | 0.77 | — | — | |
| SCHEMBL3506422 | 0.74 | CRBN (0.39) | — | |
| SCHEMBL4378123 | 0.74 | CRBN (0.39) | — | |
| SCHEMBL3506421 | 0.74 | CRBN (0.39) | — | |
| SCHEMBL18708926 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023170025-A1 | AMIDO CYCLOPROPYL DERIVATIVES AS LPA RECEPTOR INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2023-09-14 | — | — | WO | disclosed |
| US-20230250093-A1 | AMIDO CYCLOHEXANE ACID DERIVATIVES AS LPA RECEPTOR INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2023-08-10 | — | — | US | disclosed |
| WO-2023118253-A1 | CYCLOHEXANE ACID DERIVATIVES AS LPA RECEPTOR INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2023-06-29 | — | — | WO | disclosed |
| CN-115989220-A | Amido cyclohexanoic acid derivatives as LPA receptor inhibitors | 奇斯药制品公司 | 2023-04-18 | — | — | CN | disclosed |
| CN-115916196-A | Heteroaromatic macrocyclic ether chemotherapeutic agents | 纽威伦特公司 | 2023-04-04 | — | — | CN | disclosed |
| US-20220402925-A1 | COMPOUNDS AND METHODS FOR THE TREATMENT OF CYSTIC FIBROSIS | FLATLEY DISCOVERY LAB LLC (US) | 2022-12-22 | — | — | US | disclosed |
| WO-2021113795-A1 | COMPOUNDS AND METHODS FOR THE TREATMENT OF CYSTIC FIBROSIS | FLATLEY DISCOVERY LAB, LLC (US) | 2021-06-10 | — | — | WO | disclosed |
| WO-2017202275-A1 | BROMO BENZYL ETHER DERIVATIVE, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION AND USES THEREOF | 中国医学科学院药物研究所 | 2017-11-30 | — | — | WO | disclosed |
| WO-2017202274-A1 | NICOTINYL ALCOHOL ETHER DERIVATIVE, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION AND USES THEREOF | 中国医学科学院药物研究所 | 2017-11-30 | — | — | WO | disclosed |
| WO-2017202273-A1 | BENZYL PHENYL ETHER DERIVATIVE, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION AND USES THEREOF | 中国医学科学院药物研究所 | 2017-11-30 | — | — | WO | disclosed |
| WO-2017202276-A1 | PHENYLATE DERIVATIVE, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION AND USES THEREOF | 中国医学科学院药物研究所 | 2017-11-30 | — | — | WO | disclosed |