Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 5/20 | 0.54 |
| ▸ | CDK8 | P49336 | 5/20 | 0.54 |
| ▸ | PLAU | P00749 | 1/20 | 0.46 |
| ▸ | NQO2 | P16083 | 1/20 | 0.44 |
| ▸ | RAF1 | P04049 | 1/20 | 0.44 |
| ▸ | PLK1 | P53350 | 2/20 | 0.43 |
| ▸ | CYP17A1 | P05093 | 4/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.41 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.41 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.41 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.41 |
| ▸ | IP6K2 | Q9UHH9 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9907610 | 0.81 | ATM (0.50) | — | |
| SCHEMBL10138554 | 0.76 | CCNC (0.68) | CCNCCDK8MKNK1MKNK2 | |
| SCHEMBL30824507 | 0.74 | PLAU (0.53) | PLAUPLK1CYP17A1CYP3A4MKNK1 | |
| SCHEMBL17643849 | 0.74 | SMYD3 (0.57) | PLAUPLK1CYP17A1CYP3A4MKNK1 | |
| SCHEMBL14493611 | 0.71 | PLAU (0.57) | PLAUPLK1CYP17A1CYP3A4HDAC8 | |
| SCHEMBL4141704 | 0.70 | KMT2A (0.56) | PLAUHDAC8HDAC6HDAC2 | |
| SCHEMBL8404562 | 0.70 | CYP1A2 (0.52) | — | |
| SCHEMBL19296076 | 0.70 | PLAU (0.51) | CDK8PLAUPLK1CYP17A1CYP3A4 | |
| SCHEMBL4730778 | 0.70 | KDM4E (0.46) | CCNCCDK8PLAUNQO2CYP3A4 | |
| SCHEMBL5909485 | 0.69 | RAF1 (0.53) | RAF1PLK1MKNK1MKNK2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017205536-A2 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2017-11-30 | — | — | WO | disclosed |