Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 1/20 | 0.46 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.43 |
| ▸ | HTR3A | P46098 | 5/20 | 0.43 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.43 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | PTGES | O14684 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | ELANE | P08246 | 1/20 | 0.41 |
| ▸ | TOP2A | P11388 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24162868 | 0.82 | KMT2A (0.67) | ESR1MAPTMAPK10KMT2APTGES | |
| SCHEMBL496431 | 0.82 | MAOB (0.49) | ESR1MAPTMAPK10KMT2AELANE | |
| SCHEMBL6840173 | 0.82 | ELANE (0.44) | HTR3AESR1MAPTMAPK10KMT2A | |
| SCHEMBL1398896 | 0.81 | TOP2A (0.59) | PKN1PKN2MAPTKMT2AGAA | |
| SCHEMBL7446156 | 0.81 | PARP1 (0.53) | ELANEALDH1A1 | |
| SCHEMBL22822215 | 0.81 | PLK1 (0.43) | PLK1CREBBPHTR3APKN1PKN2 | |
| SCHEMBL24162880 | 0.79 | KDM4E (0.65) | HTR3AKCNH2ALDH1A1 | |
| SCHEMBL21807110 | 0.79 | TOP2A (0.44) | ESR1MAPTMAPK10KMT2APTGES | |
| SCHEMBL19576105 | 0.78 | KDM4E (0.67) | HTR3APOLBKCNH2ALDH1A1 | |
| SCHEMBL24163456 | 0.77 | HPGD (0.52) | MAPTKMT2AGAAPOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017205536-A2 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2017-11-30 | — | — | WO | disclosed |